Protein: ELYS
Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)

Gene: ELYS, AHCTF1
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q8WYP5

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

386036

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

5

13

High-throughput

0.702

High

1085259

NU160
Nuclear pore complex protein Nup160

4

2

Small-scale

0.677

High

1361683

VAPA
Vesicle-associated membrane protein-associated protein A

2

3

High-throughput

0.628

High

1356912

NU133
Nuclear pore complex protein Nup133

3

0

Small-scale

0.613

High

154857

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

2

1

High-throughput

0.611

High

1101290

SLAF1
Signaling lymphocytic activation molecule

2

4

High-throughput

0.611

High

1339086

NUP37
Nucleoporin Nup37

2

12

Small-scale

0.611

High

372703

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.584

High

558292

XRCC6
X-ray repair cross-complementing protein 6

2

6

High-throughput

0.584

High

945284

NU107
Nuclear pore complex protein Nup107

2

1

Small-scale

0.584

High

980965

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

998610

H31
Histone H3.1

2

15

High-throughput

0.584

High

1338871

NUP43
Nucleoporin Nup43

2

20

High-throughput

0.584

High

1128930

I13R2
Interleukin-13 receptor subunit alpha-2

2

6

High-throughput

0.574

High

396610

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1339111

NUP35
Nucleoporin NUP35

2

0

High-throughput

0.559

High

333122

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

3

High-throughput

0.558

High

291844

STK16
Serine/threonine-protein kinase 16

1

6

High-throughput

0.536

High

348631

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

447263

NPM
Nucleophosmin

1

4

High-throughput

0.536

High

520944

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

593455

PGFRA
Platelet-derived growth factor receptor alpha

1

8

High-throughput

0.536

High

601785

HMGA1
High mobility group protein HMG-I/HMG-Y

1

5

High-throughput

0.536

High

909118

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.536

High

1134661

NUMA1
Nuclear mitotic apparatus protein 1

1

14

High-throughput

0.536

High

1163097

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1249725

AEGP
Apical endosomal glycoprotein

1

1

High-throughput

0.536

High

436958

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.515

High

437287

K2C8
Keratin, type II cytoskeletal 8

1

4

High-throughput

0.515

High

474865

VIME
Vimentin

1

18

High-throughput

0.515

High

1143208

PLEC
Plectin

1

9

High-throughput

0.515

High

260924

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

407672

S100B
Protein S100-B

1

0

High-throughput

0.513

High

486596

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

488830

FURIN
Furin

1

0

High-throughput

0.513

High

749246

CD70
CD70 antigen

1

0

High-throughput

0.513

High

829909

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.513

High

1324833

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

967884

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

16

Small-scale

0.501

High

1151426

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.493

High

182694

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

220183

TNF14
Tumor necrosis factor ligand superfamily member 14

1

2

High-throughput

0.489

High

380463

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.489

High

1038461

TIE2
Angiopoietin-1 receptor

1

9

High-throughput

0.489

High

1057105

FMOD
Fibromodulin

1

1

High-throughput

0.489

High

1098928

KLRD1
Natural killer cells antigen CD94

1

2

High-throughput

0.489

High

1102953

ITAD
Integrin alpha-D

1

1

High-throughput

0.489

High

1127448

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1361685

CLC2D
C-type lectin domain family 2 member D

1

2

High-throughput

0.489

High

1361687

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.489

High

1361688

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

4

High-throughput

0.489

High

1361689

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.489

High

129293

MEN1
Menin

1

3

High-throughput

0.479

High

157681

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

174574

TRI66
Tripartite motif-containing protein 66

1

12

High-throughput

0.479

High

256936

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

260226

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

285386

EED
Polycomb protein EED

1

17

High-throughput

0.479

High

291462

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

331192

KI20A
Kinesin-like protein KIF20A

1

14

High-throughput

0.479

High

401219

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

414307

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

449763

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.479

High

589279

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

606947

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

611260

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

634555

LMNB1
Lamin-B1

1

13

High-throughput

0.479

High

655872

TBG1
Tubulin gamma-1 chain

1

4

Small-scale

0.479

High

696066

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

697198

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

720284

UFO
Tyrosine-protein kinase receptor UFO

1

14

High-throughput

0.479

High

764923

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

768764

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

786752

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

16

High-throughput

0.479

High

791586

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

851619

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

862329

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

868566

RL29
Large ribosomal subunit protein eL29

1

2

High-throughput

0.479

High

879310

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

883296

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

894943

EMD
Emerin

1

1

High-throughput

0.479

High

965116

WDR5
WD repeat-containing protein 5

1

11

High-throughput

0.479

High

980060

H4
Histone H4

1

6

High-throughput

0.479

High

995727

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.479

High

1004897

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1008819

RED1
Double-stranded RNA-specific editase 1

1

11

High-throughput

0.479

High

1014170

CBX1
Chromobox protein homolog 1

1

10

High-throughput

0.479

High

1017067

H33
Histone H3.3

1

15

High-throughput

0.479

High

1040865

MECOM
Histone-lysine N-methyltransferase MECOM

1

4

High-throughput

0.479

High

1045581

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1096772

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

1097452

CBX3
Chromobox protein homolog 3

1

10

High-throughput

0.479

High

1113858

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1137421

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1137896

TNIP1
TNFAIP3-interacting protein 1

1

14

High-throughput

0.479

High

1140627

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1141833

EEA1
Early endosome antigen 1

1

15

High-throughput

0.479

High

1155598

EZH2
Histone-lysine N-methyltransferase EZH2

1

14

High-throughput

0.479

High

1161577

IF16
Gamma-interferon-inducible protein 16

1

8

High-throughput

0.479

High

1229010

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.479

High

1276555

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1289255

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

High-throughput

0.479

High

1289492

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1313299

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1346868

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1352660

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1361663

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1361664

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.479

High

1361666

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1361667

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

1361669

GCP3
Gamma-tubulin complex component 3

1

1

Small-scale

0.479

High

1361670

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

15

High-throughput

0.479

High

1361671

DNJC1
DnaJ homolog subfamily C member 1

1

8

High-throughput

0.479

High

1361673

GCP6
Gamma-tubulin complex component 6

1

1

Small-scale

0.479

High

1361676

WWTR1
WW domain-containing transcription regulator protein 1

1

14

High-throughput

0.479

High

1361677

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1361678

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1361680

ANLN
Anillin

1

5

High-throughput

0.479

High

1361681

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

1361682

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1361684

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1361686

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

1361675

NUP85
Nuclear pore complex protein Nup85

1

0

Small-scale

0.458

High

48991

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

380108

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

380568

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

2

High-throughput

0.445

High

642995

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

787056

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.437

High

850901

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

1

2

High-throughput

0.437

High

1254846

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1361668

FAF2
FAS-associated factor 2

1

2

High-throughput

0.437

High

749371

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

1159216

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1350847

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1361672

OPALI
Opalin

1

0

High-throughput

0.279

Low

1361690

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

1249062

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1276252

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low

1361665

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1361674

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

190447

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

1316213

S22AF
Solute carrier family 22 member 15

1

0

High-throughput

0.232

Low

1361679

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025