HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: AKA12 (Q02952)
A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)
Gene: AKAP12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1782
+	Hs
		749718 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (21-962): 3.34e-13: 77.6: 11.72
+	Hs
		749499 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MDC1_HUMAN (22-1697): 4.38e-13: 77: 12.50
+	Hs
		749197 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31
+	Hs
		749592 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NIPBL_HUMAN (9-656): 3.6e-10: 67.7: 13.63
+	Hs
		152673 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		KMT2D_HUMAN (47-764): 3.85e-43: 176: 11.48
+	Hs
		1056907 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		MDC1_HUMAN (22-1697): 4.38e-13: 77: 12.50
+	Hs
		1019387 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		SRRM2_HUMAN (4-1096): 6.49e-11: 70: 7.25
+	Hs
		1056954 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MDC1_HUMAN (22-1697): 4.38e-13: 77: 12.50
+	Hs
		801335 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31
+	Hs
		1305982 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		SRRM2_HUMAN (4-1096): 6.49e-11: 70: 7.25
+	Ce
		136802 UNC89_CAEEL (434-1630): 9.57e-17: 89.4: 11.68		UNC22_CAEEL (8-810): 1.35e-10: 69.3: 11.98