HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0015631 - tubulin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1278
+	Hs
		725099 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		675126 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Hs
		724691 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		551628 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Hs
		584960 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		1019301 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		522639 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH7_HUMAN (64-763): 2.65e-27: 122: 9.80
+	Hs
		528393 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH6_HUMAN (47-712): 5.82e-26: 118: 9.71
+	Hs
		725238 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		725005 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Mm
		1093546 TRI72_MOUSE (18-91): 9.41e-12: 71.5: 30.26		MYH9_MOUSE (826-1275): 8.37e-15: 82.2: 10.13