Protein: NLRP3
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)

Gene: NLRP3
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q96P20

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002674 - negative regulation of acute inflammatory response
GO:0002830 - positive regulation of type 2 immune response
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1399406

ASC
Apoptosis-associated speck-like protein containing a CARD

25

18

Small-scale

0.989

High

1351862

NEK7
Serine/threonine-protein kinase Nek7

11

3

Small-scale

0.974

High

1399385

NLRP3
NACHT, LRR and PYD domains-containing protein 3

4

17

Small-scale

0.871

High

1399405

FBXL2
F-box/LRR-repeat protein 2

2

16

Small-scale

0.825

High

194785

MEFV
Pyrin

2

13

Small-scale

0.754

High

279206

ULK1
Serine/threonine-protein kinase ULK1

2

2

Small-scale

0.754

High

624121

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

8

Small-scale

0.724

High

876972

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.724

High

1399388

TXNIP
Thioredoxin-interacting protein

6

1

Small-scale

0.721

High

1278078

MAVS
Mitochondrial antiviral-signaling protein

5

4

Small-scale

0.706

High

712886

CASP1
Caspase-1

5

20

Small-scale

0.702

High

858800

BRCC3
Lys-63-specific deubiquitinase BRCC36

5

4

Small-scale

0.702

High

947391

NALP5
NACHT, LRR and PYD domains-containing protein 5

1

17

High-throughput

0.691

High

1115924

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.691

High

1396675

MARK4
MAP/microtubule affinity-regulating kinase 4

1

0

Small-scale

0.687

High

1399387

TRI31
E3 ubiquitin-protein ligase TRIM31

3

15

Small-scale

0.670

High

1399394

NLRC4
NLR family CARD domain-containing protein 4

1

20

Small-scale

0.665

High

1399392

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

17

Small-scale

0.653

High

242633

PRKN
E3 ubiquitin-protein ligase parkin

3

9

Small-scale

0.646

High

1399391

MARH7
E3 ubiquitin-protein ligase MARCHF7

2

2

Small-scale

0.634

High

1399404

HERC5
E3 ISG15--protein ligase HERC5

2

5

Small-scale

0.634

High

543533

VDR
Vitamin D3 receptor

2

5

Small-scale

0.624

High

1327139

FBXL6
F-box/LRR-repeat protein 6

1

10

High-throughput

0.618

High

227644

SPOP
Speckle-type POZ protein

1

1

Small-scale

0.618

High

562636

RINI
Ribonuclease inhibitor

1

19

High-throughput

0.618

High

631417

RAB5A
Ras-related protein Rab-5A

1

4

Small-scale

0.618

High

461828

HS90A
Heat shock protein HSP 90-alpha

2

12

Small-scale

0.601

High

340664

STABP
STAM-binding protein

2

1

Small-scale

0.595

High

1399409

FAF1
FAS-associated factor 1

1

6

Small-scale

0.586

High

1108056

SQSTM
Sequestosome-1

2

5

Small-scale

0.584

High

1399390

DHX33
ATP-dependent RNA helicase DHX33

2

2

Small-scale

0.584

High

878541

PAXI
Paxillin

1

1

Small-scale

0.573

High

1112663

CUL1
Cullin-1

1

12

Small-scale

0.568

High

49998

IRGM
Immunity-related GTPase family M protein

1

2

Small-scale

0.561

High

1294327

TRI50
E3 ubiquitin-protein ligase TRIM50

1

14

Small-scale

0.561

High

1331600

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

3

Small-scale

0.553

High

1393918

ABHD8
Protein ABHD8

1

0

Small-scale

0.537

High

126170

AP3B1
AP-3 complex subunit beta-1

1

1

High-throughput

0.536

High

243704

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

3

High-throughput

0.536

High

259057

DNJA2
DnaJ homolog subfamily A member 2

1

7

High-throughput

0.536

High

320352

PHF14
PHD finger protein 14

1

2

High-throughput

0.536

High

330496

LC7L3
Luc7-like protein 3

1

1

High-throughput

0.536

High

462577

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.536

High

574432

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

595565

H15
Histone H1.5

1

2

High-throughput

0.536

High

599863

YBOX3
Y-box-binding protein 3

1

2

High-throughput

0.536

High

849228

KSYK
Tyrosine-protein kinase SYK

1

11

Small-scale

0.536

High

853381

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.536

High

1097502

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.536

High

1158965

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.536

High

1286255

PCGF5
Polycomb group RING finger protein 5

1

8

High-throughput

0.536

High

1324533

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

1

High-throughput

0.536

High

1399386

FEM1A
Protein fem-1 homolog A

1

3

High-throughput

0.536

High

1399399

MTCH1
Mitochondrial carrier homolog 1

1

7

High-throughput

0.536

High

1399402

SPAST
Spastin

1

2

High-throughput

0.536

High

1399403

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.536

High

1399412

SGT1
Protein SGT1 homolog

1

13

Small-scale

0.529

High

1399407

APC10
Anaphase-promoting complex subunit 10

1

0

Small-scale

0.529

High

697997

CALR
Calreticulin

1

2

High-throughput

0.515

High

788154

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.515

High

167118

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.513

High

169010

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

542168

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

1315474

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.513

High

1328341

ZC3H8
Zinc finger CCCH domain-containing protein 8

1

0

High-throughput

0.513

High

1399389

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.513

High

1399393

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

697361

CD82
CD82 antigen

1

1

Small-scale

0.512

High

1233426

LTOR1
Ragulator complex protein LAMTOR1

1

2

Small-scale

0.504

High

532880

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

1399395

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.489

High

1399396

NECT3
Nectin-3

1

2

High-throughput

0.489

High

131499

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

Small-scale

0.479

High

180902

TIF1A
Transcription intermediary factor 1-alpha

1

12

Small-scale

0.479

High

325990

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

Small-scale

0.479

High

335170

ARI2
E3 ubiquitin-protein ligase ARIH2

1

6

Small-scale

0.479

High

378576

IL1B
Interleukin-1 beta

1

2

Small-scale

0.479

High

537734

HSP7C
Heat shock cognate 71 kDa protein

1

11

Small-scale

0.479

High

557435

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

700476

PSB8
Proteasome subunit beta type-8

1

3

Small-scale

0.479

High

853514

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

5

Small-scale

0.479

High

930019

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

Small-scale

0.479

High

983943

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

1097953

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.479

High

1100265

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

1114048

CUL3
Cullin-3

1

12

Small-scale

0.479

High

1115007

CUL4A
Cullin-4A

1

12

High-throughput

0.479

High

1115367

CUL4B
Cullin-4B

1

12

High-throughput

0.479

High

1126746

BECN1
Beclin-1

1

6

Small-scale

0.479

High

1148639

SF3A2
Splicing factor 3A subunit 2

1

1

Small-scale

0.479

High

1227290

A16L1
Autophagy-related protein 16-1

1

7

Small-scale

0.479

High

1243365

TRI40
E3 ubiquitin ligase TRIM40

1

13

Small-scale

0.479

High

1245053

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1257985

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

2

Small-scale

0.479

High

1350943

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

Small-scale

0.479

High

1371369

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

Small-scale

0.479

High

1371508

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

Small-scale

0.479

High

1389539

RN125
E3 ubiquitin-protein ligase RNF125

1

17

Small-scale

0.479

High

1392282

ZDH12
Palmitoyltransferase ZDHHC12

1

1

Small-scale

0.479

High

1399400

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.479

High

1399401

HDAC6
Protein deacetylase HDAC6

1

4

Small-scale

0.479

High

1399408

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.479

High

1399410

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1399411

CARD8
Caspase recruitment domain-containing protein 8

1

13

Small-scale

0.479

High

786349

PGM1
Phosphoglucomutase-1

1

0

Small-scale

0.460

High

931432

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

Small-scale

0.460

High

562328

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

Small-scale

0.458

High

1136935

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.458

High

1258246

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

Small-scale

0.458

High

1399398

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

1399413

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.458

High

96746

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.437

High

833857

P2RY2
P2Y purinoceptor 2

1

8

Small-scale

0.437

High

1273059

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

96979

E9PJ24
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.407

High

1212359

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.407

High

244394

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.279

Low

1399397

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025