HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	29656893, 17525332, 21622030, 12611903
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~BRCT_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0006281 - DNA repair GO:0006974 - DNA damage response and 1 others more... GO:0016604 - nuclear body
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 2089
+	Hs
		749432 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		749197 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		749718 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		749592 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13
+	Hs
		1056907 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1056954 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1019043 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1019019 TRI22_HUMAN (17-328): 1.3e-62: 225: 14.24		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1019103 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		801335 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		537122 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		MAGL2_HUMAN (136-1033): 1.66e-10: 68.7: 8.94
+	Hs
		1019387 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08
+	Hs
		1305982 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08