HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25184681, 26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0005886 - plasma membrane GO:0015631 - tubulin binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 2115
+	Hs
		724691 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725099 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		749516 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		518830 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		749227 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CENPF_HUMAN (1458-2037): 1.6e-10: 69.3: 9.97
+	Hs
		1061218 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Xl
		936125 Q90X96_XENLA (1-846): 8.6e-74: 275: 22.02		P70012_XENLA (358-2114): 5.9e-60: 231: 10.33
+	Hs
		522639 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH7_HUMAN (947-2023): 1.11e-36: 155: 11.21
+	Hs
		584968 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		528393 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH6_HUMAN (1-883): 5.66e-32: 139: 13.37
+	Xl
		936124 Q90X95_XENLA (9-373): 1.07e-26: 120: 12.75		P70012_XENLA (358-2114): 5.9e-60: 231: 10.33
+	Mm
		93758 TRI27_MOUSE (13-390): 9.45e-70: 246: 11.74		E9QAH1_MOUSE (1088-2076): 1.38e-19: 98.9: 10.39
+	Hs
		1019325 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		CNTRL_HUMAN (3-811): 1.27e-16: 89.3: 11.29
+	Hs
		725005 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725238 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Mm
		1093546 TRI72_MOUSE (18-91): 9.41e-12: 71.5: 30.26		MYH9_MOUSE (1089-2070): 6.61e-40: 165: 12.96