HitPredict

Interactor 1: YPT31 (P38555)
GTP-binding protein YPT31/YPT8 (Rab GTPase YPT31)
Gene: YPT31

Interactor 2: GDI1 (P39958)
Rab GDP-dissociation inhibitor (Rab GDI) (Secretory pathway GDP dissociation inhibitor)
Gene: GDI1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	11805826, 11805837, 16429126, 11785952, 18467557, 18426803, 17408969, 37968396, 22157956, 22940862
Identification Methods	tandem affinity purification, anti tag coimmunoprecipitation, affinity chromatography technology, two hybrid, protein complementation assay, x-ray crystallography, pull down, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0015031 - protein transport GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 223 Sc			1 451
+	Sc
		765614 YPT32_YEAST (1-223): 1.03e-84: 252: 80.72		GDI1_YEAST (1-451): 0: 667: 100.00
+	Hs
		678341 RAB14_HUMAN (1-222): 7.32e-89: 262: 46.85		GDIA_HUMAN (6-450): 0: 652: 53.81
+	Hs
		838621 RAB14_HUMAN (1-222): 7.32e-89: 262: 46.85		GDIB_HUMAN (6-450): 0: 651: 54.04
+	Mm
		838709 RAB1A_MOUSE (1-223): 8.74e-87: 256: 41.70		GDIA_MOUSE (6-450): 0: 653: 54.04
+	Hs
		678344 RAB1A_HUMAN (1-223): 8.74e-87: 256: 41.70		GDIA_HUMAN (6-450): 0: 652: 53.81
+	Hs
		838625 RAB1A_HUMAN (1-223): 8.74e-87: 256: 41.70		GDIB_HUMAN (6-450): 0: 651: 54.04
+	Dm
		185708 O18335_DROME (1-223): 1.96e-95: 279: 58.30		Q9VLB7_DROME (6-448): 0: 625: 53.38
+	Hs
		678377 RAB2B_HUMAN (8-223): 5.14e-85: 252: 41.67		GDIA_HUMAN (6-450): 0: 652: 53.81
+	Hs
		838669 RAB2B_HUMAN (8-223): 5.14e-85: 252: 41.67		GDIB_HUMAN (6-450): 0: 651: 54.04
+	Sp
		568530 YPT3_SCHPO (4-223): 4.39e-90: 265: 59.28		GDI1_SCHPO (6-451): 0: 630: 61.44
+	Dm
		185694 O18335_DROME (1-223): 1.96e-95: 279: 58.30		RABEP_DROME (6-435): 5.71e-139: 410: 24.14
+	Sc
		699423 YPT31_YEAST (1-223): 3.98e-90: 266: 100.00		RAEP_YEAST (5-385): 5.77e-114: 348: 25.30
+	Hs
		622574 RAB14_HUMAN (1-222): 7.32e-89: 262: 46.85		RAE1_HUMAN (4-62): 1.22e-15: 81.2: 40.68
+	Hs
		642721 RAB14_HUMAN (1-222): 7.32e-89: 262: 46.85		RAE2_HUMAN (4-73): 2.02e-15: 80.4: 35.71
+	Hs
		622577 RAB1A_HUMAN (1-223): 8.74e-87: 256: 41.70		RAE1_HUMAN (4-62): 1.22e-15: 81.2: 40.68
+	Hs
		642723 RAB1A_HUMAN (1-223): 8.74e-87: 256: 41.70		RAE2_HUMAN (4-73): 2.02e-15: 80.4: 35.71
+	Hs
		622604 RAB2B_HUMAN (8-223): 5.14e-85: 252: 41.67		RAE1_HUMAN (4-62): 1.22e-15: 81.2: 40.68
+	Hs
		642736 RAB2B_HUMAN (8-223): 5.14e-85: 252: 41.67		RAE2_HUMAN (4-73): 2.02e-15: 80.4: 35.71
+	Hs
		622590 RB11B_HUMAN (1-223): 5.64e-84: 250: 59.19		RAE1_HUMAN (4-62): 1.22e-15: 81.2: 40.68
+	Hs
		642730 RB11B_HUMAN (1-223): 5.64e-84: 250: 59.19		RAE2_HUMAN (4-73): 2.02e-15: 80.4: 35.71