Protein: PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]

Gene: PGBM, HSPG2
Organism: Homo sapiens
Interactions: 84
UniProt ID: P98160

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001540 - amyloid-beta binding
GO:0001666 - response to hypoxia
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

729641

VGFR2
Vascular endothelial growth factor receptor 2

2

14

Small-scale

0.831

High

363077

FINC
Fibronectin

2

17

Small-scale

0.799

High

399145

FGF1
Fibroblast growth factor 1

2

7

Small-scale

0.789

High

957263

FBLN2
Fibulin-2

2

15

Small-scale

0.778

High

447034

FGF2
Fibroblast growth factor 2

2

7

Small-scale

0.768

High

601115

FGF7
Fibroblast growth factor 7

1

7

Small-scale

0.740

High

182133

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

2

High-throughput

0.737

High

572620

VGFR1
Vascular endothelial growth factor receptor 1

1

9

Small-scale

0.730

High

441822

FGF4
Fibroblast growth factor 4

1

7

High-throughput

0.691

High

532926

PRG2
Bone marrow proteoglycan

1

7

High-throughput

0.691

High

885370

LOXL3
Lysyl oxidase homolog 3

1

6

High-throughput

0.691

High

957551

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.691

High

957552

CAMKV
CaM kinase-like vesicle-associated protein

1

3

High-throughput

0.691

High

957561

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.691

High

957559

TINAL
Tubulointerstitial nephritis antigen-like

3

1

High-throughput

0.667

High

660464

GRN
Progranulin

3

1

Small-scale

0.661

High

350960

PDGFB
Platelet-derived growth factor subunit B

1

2

Small-scale

0.647

High

376369

PDGFA
Platelet-derived growth factor subunit A

1

2

Small-scale

0.647

High

528090

BMP1
Bone morphogenetic protein 1

1

4

Small-scale

0.647

High

536131

HGF
Hepatocyte growth factor

1

6

Small-scale

0.647

High

549568

VEGFA
Vascular endothelial growth factor A, long form

1

2

Small-scale

0.647

High

631060

LAMA1
Laminin subunit alpha-1

1

15

Small-scale

0.647

High

851135

PRELP
Prolargin

1

4

Small-scale

0.647

High

957540

NID2
Nidogen-2

1

12

Small-scale

0.647

High

957542

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

12

Small-scale

0.647

High

174287

TELT
Telethonin

1

1

High-throughput

0.625

High

507951

FGFR1
Fibroblast growth factor receptor 1

1

7

Small-scale

0.618

High

609252

FGFR3
Fibroblast growth factor receptor 3

1

8

Small-scale

0.618

High

957565

FBX6
F-box only protein 6

3

13

High-throughput

0.599

High

957569

LOXL2
Lysyl oxidase homolog 2

1

6

Small-scale

0.575

High

957563

ZN408
Zinc finger protein 408

2

3

High-throughput

0.574

High

957545

IFIX
Pyrin and HIN domain-containing protein 1

2

6

High-throughput

0.558

High

760522

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

8

Small-scale

0.552

High

363585

TTHY
Transthyretin

1

0

Small-scale

0.537

High

211359

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

233937

GDF9
Growth/differentiation factor 9

1

3

High-throughput

0.536

High

262430

TULP3
Tubby-related protein 3

1

2

High-throughput

0.536

High

487004

LYAG
Lysosomal alpha-glucosidase

1

2

High-throughput

0.536

High

535627

EDN3
Endothelin-3

1

2

High-throughput

0.536

High

606874

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

725947

ADDA
Alpha-adducin

1

6

High-throughput

0.536

High

924478

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.536

High

941843

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

3

High-throughput

0.536

High

957537

IL5RA
Interleukin-5 receptor subunit alpha

1

10

High-throughput

0.536

High

957546

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

957568

FBX2
F-box only protein 2

1

13

High-throughput

0.536

High

957541

FGFP1
Fibroblast growth factor-binding protein 1

1

0

Small-scale

0.529

High

236361

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.513

High

957557

IL17F
Interleukin-17F

1

0

High-throughput

0.513

High

132305

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

3

High-throughput

0.508

High

957544

GFI1B
Zinc finger protein Gfi-1b

1

2

High-throughput

0.508

High

431739

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

475628

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

485116

GLI3
Transcriptional activator GLI3

1

3

High-throughput

0.500

High

241744

CCD22
Coiled-coil domain-containing protein 22

1

8

High-throughput

0.489

High

785859

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.489

High

957543

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.489

High

957547

FIGLA
Factor in the germline alpha

1

2

High-throughput

0.489

High

957548

H2BWT
Histone H2B type W-T

1

15

High-throughput

0.489

High

957550

ZN444
Zinc finger protein 444

1

3

High-throughput

0.489

High

957564

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.489

High

957566

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.489

High

205274

TGON2
Trans-Golgi network integral membrane protein 2

1

15

High-throughput

0.479

High

302385

CSTN1
Calsyntenin-1

1

5

Small-scale

0.479

High

344966

CYTN
Cystatin-SN

1

4

Small-scale

0.479

High

521256

SKI
Ski oncogene

1

2

Small-scale

0.479

High

657668

LYOX
Protein-lysine 6-oxidase

1

4

Small-scale

0.479

High

873781

MFAP2
Microfibrillar-associated protein 2

1

1

Small-scale

0.479

High

957538

CUL3
Cullin-3

1

15

High-throughput

0.479

High

957549

CLC14
C-type lectin domain family 14 member A

1

3

Small-scale

0.479

High

957554

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

957558

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

869451

ATN1
Atrophin-1

1

4

High-throughput

0.464

High

719447

MERL
Merlin

1

9

High-throughput

0.445

High

181095

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

832370

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

957539

CUL4A
Cullin-4A

1

15

High-throughput

0.437

High

957555

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.437

High

957556

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.437

High

957560

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

6

Small-scale

0.437

High

957562

WDR76
WD repeat-containing protein 76

1

12

High-throughput

0.437

High

957567

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.437

High

957553

ESR2
Estrogen receptor beta

1

14

High-throughput

0.407

High

330195

PTTG1
Securin

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024