HitPredict

Interactor 1: VATA (P38606)
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
Gene: ATP6V1A

Interactor 2: VATC2 (Q8NEY4)
V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)
Gene: ATP6V1C2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 617 Hs			1 427
+	Hs
		597725 VATA_HUMAN (1-617): 0: 840: 100.00		VATC1_HUMAN (1-427): 1.67e-179: 507: 55.61
+	Mm
		840090 VATA_MOUSE (1-617): 0: 837: 98.06		VATC1_MOUSE (1-427): 9.17e-179: 505: 55.61
+	Dm
		1099689 VATA2_DROME (4-617): 0: 822: 83.55		VATC_DROME (1-96): 2.6e-32: 131: 56.70
+	Dm
		820543 VATA1_DROME (4-617): 0: 812: 83.06		VATC_DROME (1-96): 2.6e-32: 131: 56.70
+	Sc
		566544 VATA_YEAST (255-617): 2.34e-132: 416: 59.78		VATC_YEAST (7-423): 8.37e-135: 394: 30.73
+	Dm
		680172 VATB_DROME (140-542): 4.92e-124: 377: 20.53		VATC_DROME (1-96): 2.6e-32: 131: 56.70