Protein: ERCC6
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)

Gene: ERCC6
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q03468

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000077 - DNA damage checkpoint signaling
GO:0000303 - response to superoxide
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042854

ERCC8
DNA excision repair protein ERCC-8

13

20

Small-scale

0.981

High

667277

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

12

Small-scale

0.928

High

1042853

RBBP4
Histone-binding protein RBBP4

4

20

Small-scale

0.873

High

418949

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.819

High

1027394

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

20

Small-scale

0.789

High

1042872

RBBP7
Histone-binding protein RBBP7

2

20

High-throughput

0.755

High

339969

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

12

Small-scale

0.754

High

722942

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

5

Small-scale

0.754

High

754809

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.724

High

979535

H4
Histone H4

1

17

Small-scale

0.724

High

998236

H31
Histone H3.1

1

20

Small-scale

0.724

High

1042913

MPP8
M-phase phosphoprotein 8

1

8

High-throughput

0.691

High

1042907

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

12

Small-scale

0.670

High

413669

P53
Cellular tumor antigen p53

3

10

Small-scale

0.667

High

807383

IF4A3
Eukaryotic initiation factor 4A-III

1

20

High-throughput

0.647

High

958088

ARP3
Actin-related protein 3

1

19

High-throughput

0.647

High

958248

ARP2
Actin-related protein 2

1

17

High-throughput

0.647

High

1042848

ERCC6
DNA excision repair protein ERCC-6

1

18

High-throughput

0.647

High

1042874

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

18

High-throughput

0.647

High

1042901

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

13

High-throughput

0.647

High

704737

ERCC5
DNA excision repair protein ERCC-5

3

1

Small-scale

0.646

High

1042858

HDAC1
Histone deacetylase 1

3

20

Small-scale

0.646

High

1042871

DDB1
DNA damage-binding protein 1

3

8

Small-scale

0.640

High

487215

PARP1
Poly [ADP-ribose] polymerase 1

2

20

Small-scale

0.634

High

799017

BRCA1
Breast cancer type 1 susceptibility protein

2

18

Small-scale

0.624

High

693703

RL10
Large ribosomal subunit protein uL16

2

5

High-throughput

0.619

High

141434

DDX3X
ATP-dependent RNA helicase DDX3X

1

18

Small-scale

0.618

High

209251

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

20

Small-scale

0.618

High

243608

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

18

Small-scale

0.618

High

338821

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.618

High

608555

DDX5
Probable ATP-dependent RNA helicase DDX5

1

18

Small-scale

0.618

High

621629

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

7

Small-scale

0.618

High

622797

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

20

Small-scale

0.618

High

623292

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.618

High

703296

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

19

Small-scale

0.618

High

883515

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

903136

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

18

Small-scale

0.618

High

903328

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

18

Small-scale

0.618

High

1016792

H33
Histone H3.3

1

20

High-throughput

0.618

High

1042850

CSTF1
Cleavage stimulation factor subunit 1

1

20

Small-scale

0.618

High

1042864

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

16

Small-scale

0.618

High

1042873

H2A2C
Histone H2A type 2-C

1

20

Small-scale

0.618

High

1042880

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

Small-scale

0.618

High

1042899

DDX1
ATP-dependent RNA helicase DDX1

1

20

Small-scale

0.618

High

1042904

DDX17
Probable ATP-dependent RNA helicase DDX17

1

18

Small-scale

0.618

High

1042919

DDX23
Probable ATP-dependent RNA helicase DDX23

1

20

Small-scale

0.618

High

1042925

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

17

Small-scale

0.618

High

1042932

HELLS
Lymphoid-specific helicase

1

18

Small-scale

0.618

High

1042939

DDX41
Probable ATP-dependent RNA helicase DDX41

1

20

Small-scale

0.618

High

316818

MTA2
Metastasis-associated protein MTA2

2

20

Small-scale

0.595

High

550996

PCNA
Proliferating cell nuclear antigen

2

3

Small-scale

0.595

High

559317

XRCC5
X-ray repair cross-complementing protein 5

2

11

Small-scale

0.595

High

912052

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

1

Small-scale

0.595

High

968887

PRS8
26S proteasome regulatory subunit 8

2

5

Small-scale

0.595

High

1042867

NONO
Non-POU domain-containing octamer-binding protein

2

20

Small-scale

0.595

High

1042898

P66B
Transcriptional repressor p66-beta

2

15

Small-scale

0.595

High

362251

ABL1
Tyrosine-protein kinase ABL1

1

7

Small-scale

0.586

High

934495

TERA
Transitional endoplasmic reticulum ATPase

2

5

Small-scale

0.584

High

1042859

CUL4A
Cullin-4A

2

15

Small-scale

0.584

High

1042886

CSN6
COP9 signalosome complex subunit 6

2

4

Small-scale

0.584

High

1042888

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

7

Small-scale

0.584

High

1042917

CSN4
COP9 signalosome complex subunit 4

2

1

Small-scale

0.584

High

1042943

CSN3
COP9 signalosome complex subunit 3

2

3

Small-scale

0.584

High

1042942

COR1C
Coronin-1C

1

20

High-throughput

0.579

High

1042884

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

2

0

High-throughput

0.576

High

129720

CBX4
E3 SUMO-protein ligase CBX4

1

20

High-throughput

0.575

High

654104

XPA
DNA repair protein complementing XP-A cells

2

0

Small-scale

0.569

High

1042875

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

140883

NOP56
Nucleolar protein 56

1

9

High-throughput

0.536

High

908967

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.536

High

1042852

BAX
Apoptosis regulator BAX

1

1

High-throughput

0.536

High

1042929

SYF1
Pre-mRNA-splicing factor SYF1

1

15

Small-scale

0.536

High

1042882

DCR1A
DNA cross-link repair 1A protein

1

0

Small-scale

0.529

High

1042946

RNF11
RING finger protein 11

1

1

High-throughput

0.508

High

225280

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.501

High

352112

MBD3
Methyl-CpG-binding domain protein 3

1

20

High-throughput

0.501

High

507859

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.501

High

534958

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.501

High

552794

TPR
Nucleoprotein TPR

1

20

High-throughput

0.501

High

576754

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.501

High

584013

FOSL1
Fos-related antigen 1

1

9

High-throughput

0.501

High

616302

RCC1
Regulator of chromosome condensation

1

4

High-throughput

0.501

High

625325

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.501

High

686111

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.501

High

714047

PML
Protein PML

1

18

High-throughput

0.501

High

762446

PROF2
Profilin-2

1

1

High-throughput

0.501

High

801276

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.501

High

821315

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.501

High

859240

RL5
Large ribosomal subunit protein uL18

1

5

High-throughput

0.501

High

869847

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

3

High-throughput

0.501

High

875923

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.501

High

899845

FXR1
RNA-binding protein FXR1

1

16

High-throughput

0.501

High

903554

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

2

High-throughput

0.501

High

936721

NP1L1
Nucleosome assembly protein 1-like 1

1

2

High-throughput

0.501

High

964236

SUMO2
Small ubiquitin-related modifier 2

1

19

High-throughput

0.501

High

969582

RS15A
Small ribosomal subunit protein uS8

1

7

High-throughput

0.501

High

974363

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.501

High

978887

RS6
Small ribosomal subunit protein eS6

1

6

High-throughput

0.501

High

982407

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.501

High

982631

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.501

High

984384

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.501

High

986357

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.501

High

991299

SUMO1
Small ubiquitin-related modifier 1

1

19

High-throughput

0.501

High

993511

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.501

High

994995

CSK2B
Casein kinase II subunit beta

1

5

High-throughput

0.501

High

1005848

GTF2I
General transcription factor II-I

1

1

High-throughput

0.501

High

1042855

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.501

High

1042861

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.501

High

1042863

ELOA1
Elongin-A

1

12

Small-scale

0.501

High

1042868

SF3B3
Splicing factor 3B subunit 3

1

8

High-throughput

0.501

High

1042879

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.501

High

1042885

SPT6H
Transcription elongation factor SPT6

1

10

High-throughput

0.501

High

1042892

PAF1
RNA polymerase II-associated factor 1 homolog

1

8

High-throughput

0.501

High

1042893

ZBT38
Zinc finger and BTB domain-containing protein 38

1

6

High-throughput

0.501

High

1042897

LEO1
RNA polymerase-associated protein LEO1

1

8

High-throughput

0.501

High

1042900

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.501

High

1042902

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.501

High

1042908

CUL5
Cullin-5

1

15

Small-scale

0.501

High

1042911

IWS1
Protein IWS1 homolog

1

9

High-throughput

0.501

High

1042918

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.501

High

1042928

SENP2
Sentrin-specific protease 2

1

4

High-throughput

0.501

High

1042933

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

5

High-throughput

0.501

High

1042935

SAE1
SUMO-activating enzyme subunit 1

1

2

High-throughput

0.501

High

1042936

SAE2
SUMO-activating enzyme subunit 2

1

3

High-throughput

0.501

High

1042944

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

2

High-throughput

0.501

High

158188

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.480

High

724046

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.480

High

973035

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.480

High

1042862

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.480

High

1042895

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.480

High

1042910

UIF
UAP56-interacting factor

1

0

High-throughput

0.480

High

1042923

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.480

High

1042926

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.480

High

1042947

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.480

High

1042948

CLIC4
Chloride intracellular channel protein 4

1

0

High-throughput

0.480

High

128208

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

Small-scale

0.479

High

128993

MEN1
Menin

1

8

High-throughput

0.479

High

155297

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

10

High-throughput

0.479

High

192811

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

Small-scale

0.479

High

193368

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

1

Small-scale

0.479

High

210923

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

215082

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

2

Small-scale

0.479

High

285888

SF3B1
Splicing factor 3B subunit 1

1

5

Small-scale

0.479

High

341556

EYA4
Protein phosphatase EYA4

1

16

Small-scale

0.479

High

358672

LDHA
L-lactate dehydrogenase A chain

1

3

High-throughput

0.479

High

371821

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

395958

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

437151

K2C8
Keratin, type II cytoskeletal 8

1

16

High-throughput

0.479

High

485084

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

High-throughput

0.479

High

541962

TOP1
DNA topoisomerase 1

1

8

Small-scale

0.479

High

542470

TOP2A
DNA topoisomerase 2-alpha

1

14

Small-scale

0.479

High

586277

ZEP1
Zinc finger protein 40

1

13

High-throughput

0.479

High

611660

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.479

High

617152

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.479

High

620311

NUCL
Nucleolin

1

15

Small-scale

0.479

High

621861

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

Small-scale

0.479

High

626192

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

High-throughput

0.479

High

640150

EPHA1
Ephrin type-A receptor 1

1

6

High-throughput

0.479

High

650708

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

20

High-throughput

0.479

High

655164

SFPQ
Splicing factor, proline- and glutamine-rich

1

20

Small-scale

0.479

High

695263

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

14

Small-scale

0.479

High

702932

DPOD1
DNA polymerase delta catalytic subunit

1

5

Small-scale

0.479

High

794447

RBMX
RNA-binding motif protein, X chromosome

1

13

Small-scale

0.479

High

892846

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

894694

EMD
Emerin

1

1

Small-scale

0.479

High

976087

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

Small-scale

0.479

High

1028158

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

1039482

TOP2B
DNA topoisomerase 2-beta

1

16

Small-scale

0.479

High

1042851

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

Small-scale

0.479

High

1042857

SF3B2
Splicing factor 3B subunit 2

1

3

Small-scale

0.479

High

1042860

CUL4B
Cullin-4B

1

15

Small-scale

0.479

High

1042866

TEBP
Prostaglandin E synthase 3

1

5

High-throughput

0.479

High

1042870

E2F4
Transcription factor E2F4

1

7

High-throughput

0.479

High

1042878

RIF1
Telomere-associated protein RIF1

1

7

Small-scale

0.479

High

1042881

CTR9
RNA polymerase-associated protein CTR9 homolog

1

12

Small-scale

0.479

High

1042889

P66A
Transcriptional repressor p66-alpha

1

15

Small-scale

0.479

High

1042890

SLX4
Structure-specific endonuclease subunit SLX4

1

13

High-throughput

0.479

High

1042894

FBX22
F-box only protein 22

1

4

High-throughput

0.479

High

1042896

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1042903

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.479

High

1042905

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.479

High

1042912

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

Small-scale

0.479

High

1042924

CRNL1
Crooked neck-like protein 1

1

18

Small-scale

0.479

High

1042927

SP110
Sp110 nuclear body protein

1

17

High-throughput

0.479

High

1042931

ANLN
Anillin

1

4

High-throughput

0.479

High

1042937

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1042938

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

Small-scale

0.479

High

1042940

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.479

High

262063

NBN
Nibrin

1

0

Small-scale

0.458

High

424393

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.458

High

701137

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.458

High

1042849

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1042906

XPF
DNA repair endonuclease XPF

1

0

Small-scale

0.458

High

1042915

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

131406

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.457

High

187698

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

2

High-throughput

0.457

High

477783

RM03
Large ribosomal subunit protein uL3m

1

4

High-throughput

0.457

High

717066

ECHM
Enoyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.457

High

728757

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

2

High-throughput

0.457

High

784590

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.457

High

1022248

FBLN2
Fibulin-2

1

6

High-throughput

0.457

High

1042856

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

17

High-throughput

0.457

High

1042877

FND3B
Fibronectin type III domain-containing protein 3B

1

3

High-throughput

0.457

High

1042914

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.457

High

1042921

RM13
Large ribosomal subunit protein uL13m

1

3

High-throughput

0.457

High

765425

BMI1
Polycomb complex protein BMI-1

1

15

High-throughput

0.445

High

386462

SPTA1
Spectrin alpha chain, erythrocytic 1

1

7

Small-scale

0.437

High

821675

TPOR
Thrombopoietin receptor

1

1

High-throughput

0.437

High

1042865

CUL7
Cullin-7

1

4

Small-scale

0.437

High

1042876

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

20

High-throughput

0.437

High

1042934

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

1042941

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.437

High

1042869

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.279

Low

168982

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.261

Low

460805

CATB
Cathepsin B

1

0

High-throughput

0.261

Low

984623

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.261

Low

1011063

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.261

Low

1011254

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.261

Low

1015383

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.261

Low

1042887

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.261

Low

1042891

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.261

Low

1042909

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.261

Low

1042916

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.261

Low

1042920

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.261

Low

1042922

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.261

Low

1042930

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.261

Low

1042945

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.261

Low

653267

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.249

Low

1042883

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

Small-scale

0.249

Low

616743

SDC1
Syndecan-1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025