HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	30833792, 32035614, 33961781, 17477906, 18794347, 15980415, 17679094, 34425107, 19686743, 13678583, 23261596, 16376880
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 424
+	Hs
		804120 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Mm
		803851 CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27		SKP2_MOUSE (1-424): 1.32e-92: 287: 86.32
+	Hs
		836902 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Xl
		991526 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q075B2_XENLA (1-418): 1.73e-75: 243: 55.74
+	Hs
		758347 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		FXL12_HUMAN (99-385): 2.56e-21: 96: 23.89
+	Dm
		1176646 Q7JNL9_DROME (10-163): 1.05e-09: 57.2: 19.46		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	Hs
		836907 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		FXL12_HUMAN (99-385): 2.56e-21: 96: 23.89