HitPredict

Interactor 1: IPL1 (P38991)
Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora kinase) (Increase-in-ploidy protein 1)
Gene: IPL1

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	11498592, 10975519, 19605555
Identification Methods	biochemical, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 367 Sc			1 136
+	Hs
		682163 AKT2_HUMAN (5-360): 5.77e-140: 407: 28.02		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		160506 AURKA_HUMAN (10-364): 3.18e-132: 385: 41.10		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		610712 KAPCB_HUMAN (84-360): 1.94e-132: 384: 34.04		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		160599 AURKA_HUMAN (10-364): 3.18e-132: 385: 41.10		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		610715 KAPCB_HUMAN (84-360): 1.94e-132: 384: 34.04		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Mm
		952738 AURKA_MOUSE (8-358): 1.01e-131: 384: 39.60		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Hs
		610742 KAPCB_HUMAN (84-360): 1.94e-132: 384: 34.04		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Dm
		356080 Q27393_DROME (1-358): 2.56e-126: 370: 34.95		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Sc
		730798 IPL1_YEAST (1-367): 6.18e-132: 383: 100.00		CENPA_YEAST (24-134): 7.32e-41: 137: 53.04
+	Hs
		935379 AURKC_HUMAN (94-355): 1.17e-91: 278: 48.86		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Mm
		250432 AURKB_MOUSE (97-358): 2.12e-87: 269: 46.95		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Hs
		935110 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952545 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		1086273 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		1174628 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	At
		886668 AUR1_ARATH (97-358): 1.44e-85: 262: 48.11		H31_ARATH (1-136): 1.66e-60: 184: 87.50
+	Hs
		1157219 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	Dm
		356113 AURKB_DROME (56-355): 1.48e-81: 253: 42.81		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Hs
		828423 AURKC_HUMAN (94-355): 1.17e-91: 278: 48.86		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73
+	Hs
		828344 AURKB_HUMAN (32-358): 1.74e-84: 261: 41.95		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73