HitPredict

Interactor 1: DYN2 (P39054)
Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM)
Gene: Dnm2

Interactor 2: AMPH (Q7TQF7)
Amphiphysin
Gene: AMPH

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9525921, 23640057
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0044877 - protein-containing complex binding GO:0045807 - positive regulation of endocytosis GO:0048488 - synaptic vesicle endocytosis GO:0098793 - presynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Mm			1 686
+	Rn
		139974 DYN2_RAT (1-870): 0: 1097: 99.66		AMPH_RAT (1-686): 1.11e-113: 359: 92.14
+	Hs
		827729 DYN2_HUMAN (1-870): 0: 1090: 98.16		AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16
+	Mm
		760459 DYN1_MOUSE (1-868): 0: 1042: 77.74		AMPH_MOUSE (1-686): 7.42e-129: 398: 100.00
+	Mm
		1186718 DYN3_MOUSE (1-870): 0: 1021: 78.17		AMPH_MOUSE (1-686): 7.42e-129: 398: 100.00
+	Hs
		827736 DYN1_HUMAN (1-847): 0: 1028: 79.18		AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16
+	Rn
		139973 DYN1_RAT (1-847): 0: 1021: 78.71		AMPH_RAT (1-686): 1.11e-113: 359: 92.14
+	Hs
		827766 DYN3_HUMAN (1-870): 0: 1019: 79.32		AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16
+	Hs
		840739 DYN2_HUMAN (1-870): 0: 1090: 98.16		DNMBP_HUMAN (12-686): 2.62e-64: 233: 15.57
+	Hs
		983387 DYN1_HUMAN (1-847): 0: 1028: 79.18		DNMBP_HUMAN (12-686): 2.62e-64: 233: 15.57
+	Hs
		1167839 DYN3_HUMAN (1-870): 0: 1019: 79.32		DNMBP_HUMAN (12-686): 2.62e-64: 233: 15.57
+	Hs
		840679 DYN2_HUMAN (1-870): 0: 1090: 98.16		EP300_HUMAN (107-613): 6.64e-31: 132: 11.92
+	Mm
		139029 DYN2_MOUSE (1-870): 0: 1100: 100.00		BIN1_MOUSE (417-686): 1.28e-26: 116: 24.54
+	Hs
		131222 DYN2_HUMAN (1-870): 0: 1090: 98.16		BIN1_HUMAN (328-685): 2.46e-22: 103: 25.14
+	Mm
		139028 DYN1_MOUSE (1-868): 0: 1042: 77.74		BIN1_MOUSE (417-686): 1.28e-26: 116: 24.54
+	Hs
		999221 DYN3_HUMAN (1-870): 0: 1019: 79.32		EP300_HUMAN (107-613): 6.64e-31: 132: 11.92
+	Mm
		139042 DYN3_MOUSE (1-870): 0: 1021: 78.17		BIN1_MOUSE (417-686): 1.28e-26: 116: 24.54
+	Rn
		139987 DYN1_RAT (1-847): 0: 1021: 78.71		BIN1_RAT (384-686): 4.8e-26: 115: 21.90
+	Hs
		131238 DYN1_HUMAN (1-847): 0: 1028: 79.18		BIN1_HUMAN (328-685): 2.46e-22: 103: 25.14
+	Ce
		105220 DYN1_CAEEL (3-762): 0: 947: 66.40		G5ECK4_CAEEL (182-685): 2.59e-31: 133: 11.16
+	Sc
		599466 VPS1_YEAST (7-739): 0: 696: 37.39		RV167_YEAST (11-372): 1.96e-44: 168: 17.05