HitPredict

Interactor 1: DYN1 (P39055)
Dynamin (EC 3.6.5.5)
Gene: dyn-1

Interactor 2: Q9U2T9 (Q9U2T9)
Intersectin-1
Gene: itsn-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.837

Property	Details
Experiments	17942601, 18298590, 23549480
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 830 Ce			1 1085
+	Hs
		787872 DYN2_HUMAN (5-830): 0: 982: 63.05		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Rn
		192739 DYN1_RAT (5-820): 0: 991: 62.31		SRBS2_RAT (589-1020): 1.89e-35: 148: 13.73
+	Hs
		557664 DYN1_HUMAN (5-820): 0: 996: 62.07		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Rn
		192740 DYN2_RAT (5-830): 0: 985: 63.59		SRBS2_RAT (589-1020): 1.89e-35: 148: 13.73
+	Mm
		223006 DYN1_MOUSE (5-826): 0: 995: 62.05		NCK2_MOUSE (660-958): 2.72e-26: 114: 19.47
+	Hs
		209034 DYN1_HUMAN (5-820): 0: 996: 62.07		NCK2_HUMAN (660-960): 3.34e-25: 110: 18.69
+	Ce
		711198 DYN1_CAEEL (1-762): 0: 986: 100.00		YKA7_CAEEL (665-936): 1.1e-19: 95.9: 16.61
+	Hs
		983379 DYN1_HUMAN (5-820): 0: 996: 62.07		ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35
+	Mm
		760469 DYN1_MOUSE (5-826): 0: 995: 62.05		ITSN1_MOUSE (780-940): 1.48e-14: 81: 26.95
+	Mm
		1141147 DYN3_MOUSE (5-830): 0: 1001: 63.76		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Rn
		599413 DYN1_RAT (5-820): 0: 991: 62.31		ITSN1_RAT (780-940): 1.6e-14: 81: 26.95
+	Hs
		924499 DYN1_HUMAN (5-820): 0: 996: 62.07		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Mm
		760488 DYN2_MOUSE (5-830): 0: 986: 63.59		ITSN1_MOUSE (780-940): 1.48e-14: 81: 26.95
+	Mm
		760450 DYN1_MOUSE (5-826): 0: 995: 62.05		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Hs
		840702 DYN2_HUMAN (5-830): 0: 982: 63.05		ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35
+	Rn
		599402 DYN1_RAT (5-820): 0: 991: 62.31		GRB2_RAT (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		924956 DYN3_HUMAN (5-830): 0: 987: 62.43		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Mm
		760474 DYN2_MOUSE (5-830): 0: 986: 63.59		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Hs
		840663 DYN2_HUMAN (5-830): 0: 982: 63.05		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Ce
		760506 DYN1_CAEEL (1-762): 0: 986: 100.00		Q95PW9_CAEEL (670-843): 3.79e-09: 62: 26.55