HitPredict

Interactor 1: CAP2 (P40123)
Adenylyl cyclase-associated protein 2 (CAP 2)
Gene: CAP2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	28514442, 33961781, 25416956, 25910212, 34079125, 35271311
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, split luciferase complementation, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~CAP_C
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Hs			1 375
+	Hs
		768478 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		474796 CAP2_HUMAN (1-477): 0: 698: 100.00		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		965194 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		474807 CAP1_HUMAN (1-475): 0: 651: 62.71		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		768474 CAP2_HUMAN (1-477): 0: 698: 100.00		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		768466 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		768467 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		768468 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		768465 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		891700 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929826 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932109 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		932956 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		915363 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Dm
		501544 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT1_DROME (2-375): 0: 598: 98.13
+	Dm
		501500 Q7KN55_DROME (4-474): 0: 551: 43.52		ACT1_DROME (2-375): 0: 598: 98.13
+	Dm
		361155 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT2_DROME (2-375): 0: 596: 97.59
+	Sp
		501577 CAP_SCHPO (14-473): 0: 532: 33.40		ACT_SCHPO (1-375): 0: 592: 90.40
+	Dm
		361154 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT2_DROME (2-375): 0: 596: 97.59
+	Dm
		361193 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT4_DROME (2-375): 0: 589: 94.65