HitPredict

Interactor 1: CAP2 (P40123)
Adenylyl cyclase-associated protein 2 (CAP 2)
Gene: CAP2

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	30890647, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~CAP_C
Common GO terms	GO:0005737 - cytoplasm GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Hs			1 377
+	Hs
		768462 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		768466 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		768468 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		768474 CAP2_HUMAN (1-477): 0: 698: 100.00		Q1KLZ0_HUMAN (4-377): 0: 599: 94.12
+	Hs
		768465 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTA_HUMAN (1-377): 0: 596: 98.41
+	Hs
		891700 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		929826 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		932109 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		932956 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		915363 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTA_HUMAN (1-377): 0: 596: 98.41
+	Sp
		501577 CAP_SCHPO (14-473): 0: 532: 33.40		ACT_SCHPO (4-377): 0: 645: 89.04
+	Dm
		361193 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT4_DROME (1-377): 0: 649: 92.57
+	Dm
		501544 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT1_DROME (1-377): 0: 598: 94.43
+	Dm
		501500 Q7KN55_DROME (4-474): 0: 551: 43.52		ACT1_DROME (1-377): 0: 598: 94.43
+	Dm
		361155 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT2_DROME (1-377): 0: 596: 94.16
+	Dm
		501456 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT5_DROME (1-377): 0: 598: 93.10
+	Dm
		501543 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT1_DROME (1-377): 0: 598: 94.43
+	Dm
		361154 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT2_DROME (1-377): 0: 596: 94.16
+	Dm
		862578 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT3_DROME (1-377): 0: 595: 92.57
+	Dm
		950127 Q9VPX6_DROME (4-474): 0: 527: 43.73		ACT6_DROME (1-377): 0: 594: 92.84