HitPredict

Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0043025 - neuronal cell body GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Hs			1 192
+	Hs
		770195 IL6RB_HUMAN (1-918): 0: 623: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545240 IL6RB_HUMAN (1-918): 0: 623: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		770209 IL6RB_HUMAN (1-918): 0: 623: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		770196 IL6RB_HUMAN (1-918): 0: 623: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		770190 IL6RB_HUMAN (1-918): 0: 623: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		770191 IL6RB_HUMAN (1-918): 0: 623: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436185 IL6RB_HUMAN (1-918): 0: 623: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564435 IL6RB_HUMAN (1-918): 0: 623: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		925556 OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		1305430 OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		892556 OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		436478 OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		489942 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		489896 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		489932 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		489951 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		489933 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		489936 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436131 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		489899 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49