HitPredict

Interactor 1: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Interactor 2: PSMD6 (Q9V3G7)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (Protein Rpn7)
Gene: Rpn7

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Dm			1 389
+	Hs
		656232 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSMD6_HUMAN (1-389): 1.37e-143: 414: 70.18
+	Hs
		637690 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PSMD6_HUMAN (1-389): 1.37e-143: 414: 70.18
+	Hs
		637422 PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67		PSMD6_HUMAN (1-389): 1.37e-143: 414: 70.18
+	Hs
		893673 PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49		PSMD6_HUMAN (1-389): 1.37e-143: 414: 70.18
+	Hs
		156291 PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52		PSMD6_HUMAN (1-389): 1.37e-143: 414: 70.18
+	Dm
		1278633 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		PSMD6_DROME (1-389): 6.71e-134: 390: 100.00
+	Hs
		893660 PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49		CSN1_HUMAN (15-387): 2.05e-99: 305: 19.13
+	Hs
		893638 PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49		CSN2_HUMAN (25-383): 2.05e-97: 298: 13.19
+	Sc
		689209 PSA5_YEAST (1-233): 3.17e-91: 270: 31.12		RPN7_YEAST (15-389): 8.21e-95: 291: 33.83
+	Sp
		293717 PSA2_SCHPO (3-233): 1.96e-107: 311: 58.20		RPN6_SCHPO (5-389): 2.86e-75: 241: 12.66
+	Hs
		121689 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSD11_HUMAN (3-388): 1.1e-82: 260: 13.53
+	Hs
		121684 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PSD11_HUMAN (3-388): 1.1e-82: 260: 13.53
+	Dm
		1180708 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		PSD11_DROME (5-388): 9.93e-80: 253: 13.63
+	Sc
		619512 PSA2_YEAST (3-216): 2.64e-81: 245: 59.91		RPN7_YEAST (15-389): 8.21e-95: 291: 33.83
+	Dm
		771297 PSA2_DROME (1-234): 2.1e-95: 280: 100.00		PSD11_DROME (5-388): 9.93e-80: 253: 13.63
+	Hs
		121683 PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67		PSD11_HUMAN (3-388): 1.1e-82: 260: 13.53
+	Hs
		121719 PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49		PSD11_HUMAN (3-388): 1.1e-82: 260: 13.53
+	Hs
		121635 PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52		PSD11_HUMAN (3-388): 1.1e-82: 260: 13.53
+	Sc
		689219 PSA5_YEAST (1-233): 3.17e-91: 270: 31.12		RPN6_YEAST (29-383): 2.71e-75: 241: 10.80
+	Sc
		619525 PSA2_YEAST (3-216): 2.64e-81: 245: 59.91		RPN6_YEAST (29-383): 2.71e-75: 241: 10.80