HitPredict

Interactor 1: PSA4 (P40303)
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)
Gene: PRE6

Interactor 2: BLM10 (P43583)
Proteasome activator BLM10 (Bleomycin resistance protein BLM10)
Gene: BLM10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	28733623, 37968396, 23982732, 16429126, 18927584, 24225956
Identification Methods	unspecified method, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome, BLM10_mid~Proteasome_A_N, DUF3437~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0034515 - proteasome storage granule
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 254 Sc			1 2143
+	Sc
		619369 PSA3_YEAST (4-207): 3.34e-40: 140: 35.29		BLM10_YEAST (1-2143): 0: 4138: 100.00
+	Hs
		156290 PSA7_HUMAN (4-234): 3.74e-95: 280: 58.01		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84
+	Hs
		638132 PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84
+	Hs
		893671 PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84
+	Hs
		637420 PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84
+	Hs
		656228 PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84
+	Hs
		637689 PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14		PSME4_HUMAN (1676-2142): 7.28e-167: 563: 19.84