HitPredict

Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	10491320, 17101696, 17350623
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 592
+	Hs
		771802 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Mm
		772239 VHL_MOUSE (36-213): 5.07e-113: 321: 84.27		KPCZ_MOUSE (1-592): 0: 681: 95.61
+	Hs
		623867 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		KPCL_HUMAN (6-585): 0: 568: 33.49
+	Hs
		771930 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Hs
		682144 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12
+	Hs
		681705 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Mm
		682098 VHL_MOUSE (36-213): 5.07e-113: 321: 84.27		AKT1_MOUSE (172-582): 4.54e-154: 452: 36.39