HitPredict

Interactor 1: MLH1 (P40692)
DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
Gene: MLH1

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	25416956, 32296183, 17148452, 31515488, 29892012, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 529
+	Hs
		168622 MLH1_HUMAN (1-756): 0: 1027: 100.00		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		853215 PMS2_HUMAN (5-558): 4e-143: 443: 23.12		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		853214 PMS1_HUMAN (8-486): 2.06e-128: 406: 21.36		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00