HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27880917, 27432908
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032715 - negative regulation of interleukin-6 production GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 807
+	Hs
		523222 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN22_HUMAN (1-807): 0: 1129: 100.00
+	Hs
		782777 CSK_HUMAN (1-450): 0: 543: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Mm
		782850 CSK_MOUSE (1-450): 0: 543: 99.11		PTN18_MOUSE (3-333): 8.01e-132: 401: 42.34
+	Hs
		616905 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		337361 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		522804 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		522754 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN2_HUMAN (26-399): 3.73e-129: 393: 28.76
+	Dm
		337644 ABL_DROME (5-447): 1.98e-163: 502: 38.11		LAR_DROME (6-292): 7.14e-98: 336: 35.40
+	Hs
		522756 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTPRA_HUMAN (29-290): 2.44e-104: 341: 36.33
+	Hs
		782790 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRK_HUMAN (20-292): 9.08e-61: 225: 30.96
+	Dm
		337643 ABL_DROME (5-447): 1.98e-163: 502: 38.11		PTP69_DROME (30-301): 4.9e-70: 253: 28.87
+	Hs
		617084 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		617158 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRZ_HUMAN (30-323): 4.58e-51: 196: 24.43
+	Hs
		782783 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		782792 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Dm
		337647 ABL_DROME (5-447): 1.98e-163: 502: 38.11		PTP99_DROME (31-342): 7.78e-41: 164: 21.12
+	Hs
		441186 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Mm
		337619 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		PTN11_MOUSE (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		522931 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		441169 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24