HitPredict

Interactor 1: GARS (P41250)
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)
Gene: GARS1

Interactor 2: GARS (P41250)
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)
Gene: GARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.812

The method score is based on:

Property Details
Experiments 17545306, 17595294
Identification Methods x-ray crystallography, molecular sieving, cosedimentation in solution
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HGTP_anticodon~HGTP_anticodon, HGTP_anticodon~tRNA-synt_2b, tRNA-synt_2b~tRNA-synt_2b
Common GO terms GO:0004081 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004820 - glycine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
and 10 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 739
Hs

1 739
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024