HitPredict

Interactor 1: CSK (P41241)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK)
Gene: CSK

Interactor 2: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	9221755, 20697350
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Mm			1 482
+	Mm
		337623 ABL1_MOUSE (5-446): 4.66e-165: 495: 38.14		DOK1_MOUSE (1-482): 0: 545: 100.00
+	Hs
		337542 ABL1_HUMAN (5-446): 1.08e-164: 495: 38.14		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		433460 YES_HUMAN (12-442): 1.06e-170: 491: 37.75		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		523124 SRC_HUMAN (12-442): 8.06e-171: 491: 39.78		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		789086 ABL2_HUMAN (4-445): 2.16e-161: 488: 39.38		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		235051 CSK_HUMAN (1-450): 0: 548: 99.11		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Mm
		250951 CSK_MOUSE (1-450): 0: 549: 100.00		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Mm
		337639 ABL1_MOUSE (5-446): 4.66e-165: 495: 38.14		DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30
+	Hs
		235031 ABL1_HUMAN (5-446): 1.08e-164: 495: 38.14		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235036 FYN_HUMAN (12-442): 2.68e-171: 493: 37.22		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235037 YES_HUMAN (12-442): 1.06e-170: 491: 37.75		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235040 SRC_HUMAN (12-442): 8.06e-171: 491: 39.78		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		235035 LCK_HUMAN (6-443): 1.62e-168: 485: 38.85		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Mm
		250948 ABL1_MOUSE (5-446): 4.66e-165: 495: 38.14		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Mm
		250949 SRC_MOUSE (12-442): 1.78e-169: 488: 40.00		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Hs
		151689 LCK_HUMAN (6-443): 1.62e-168: 485: 38.85		IRS4_HUMAN (6-406): 7.52e-92: 305: 14.29
+	Hs
		411805 LCK_HUMAN (6-443): 1.62e-168: 485: 38.85		FRS2_HUMAN (135-478): 2.91e-75: 247: 20.31
+	Hs
		412057 FYN_HUMAN (12-442): 2.68e-171: 493: 37.22		IRS1_HUMAN (6-360): 6.38e-68: 237: 16.01
+	Mm
		403453 SRC_MOUSE (12-442): 1.78e-169: 488: 40.00		FRS2_MOUSE (135-478): 4.6e-72: 238: 19.54
+	Dm
		1360394 SRC42_DROME (5-449): 8.91e-170: 488: 38.21		Q9W3R6_DROME (1-257): 3.27e-59: 207: 25.38