HitPredict

Interactor 1: COPB (P41810)
Coatomer subunit beta (Beta-coat protein) (Beta-COP)
Gene: SEC26

Interactor 2: COPZ (P53600)
Coatomer subunit zeta (Zeta-coat protein) (Zeta-COP)
Gene: RET3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	16554755, 16429126, 18467557, 37968396
Identification Methods	affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0000139 - Golgi membrane GO:0006886 - intracellular protein transport GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006891 - intra-Golgi vesicle-mediated transport GO:0030126 - COPI vesicle coat
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 973 Sc			1 189
+	Hs
		863360 COPB_HUMAN (3-966): 0: 961: 41.70		COPZ2_HUMAN (5-187): 1.4e-55: 176: 32.24
+	Hs
		863189 COPB_HUMAN (3-966): 0: 961: 41.70		COPZ1_HUMAN (5-187): 2.43e-52: 167: 35.52
+	Hs
		925992 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP1M1_HUMAN (11-184): 1.85e-44: 154: 15.52
+	Hs
		926066 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP1M2_HUMAN (11-184): 2.97e-43: 150: 15.52
+	Hs
		880408 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP1S2_HUMAN (9-165): 6.2e-45: 147: 16.35
+	Hs
		903681 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP1S1_HUMAN (9-171): 4.3e-44: 145: 15.39
+	Hs
		1014074 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP1M1_HUMAN (11-184): 1.85e-44: 154: 15.52
+	Hs
		925978 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP1S3_HUMAN (9-169): 1.02e-42: 142: 14.11
+	Hs
		1014107 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP1M2_HUMAN (11-184): 2.97e-43: 150: 15.52
+	Hs
		880409 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP1S2_HUMAN (9-165): 6.2e-45: 147: 16.35
+	Hs
		903682 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP1S1_HUMAN (9-171): 4.3e-44: 145: 15.39
+	Hs
		1014066 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP1S3_HUMAN (9-169): 1.02e-42: 142: 14.11
+	Hs
		864065 AP2B1_HUMAN (15-617): 2e-167: 515: 17.54		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73
+	Hs
		864070 AP1B1_HUMAN (15-610): 2.91e-163: 505: 17.58		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73
+	Dm
		1096906 Q24253_DROME (15-598): 1.05e-158: 492: 17.43		Q9VDC3_DROME (9-159): 8.95e-42: 139: 13.73
+	Ce
		725358 Q9N4F3_CAEEL (15-640): 4.37e-153: 478: 16.41		AP1M_CAEEL (11-184): 1.08e-42: 149: 13.22
+	At
		1196570 APBLB_ARATH (14-617): 8.76e-157: 486: 16.77		AP2S_ARATH (9-159): 1.08e-40: 136: 20.26
+	Zm
		30064 A0A1D6K3D9_MAIZE (51-617): 8.14e-147: 459: 16.72		Q9MAY9_MAIZE (4-186): 1.06e-46: 152: 28.34
+	At
		1196568 AP2A1_ARATH (15-860): 1.57e-145: 460: 14.40		AP2S_ARATH (9-159): 1.08e-40: 136: 20.26
+	Dm
		954832 AP2A_DROME (15-731): 7.41e-144: 454: 13.40		Q9VDC3_DROME (9-159): 8.95e-42: 139: 13.73