Protein: LSM3
LSM complex subunit LSM3 (SmX4 protein)

Gene: LSM3
Organism: Saccharomyces cerevisiae S288C
Interactions: 123
UniProt ID: P57743

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864124

LSM1
LSM1-LSM7 complex subunit LSM1

15

20

Small-scale

0.983

High

795909

LSM2
LSM complex subunit LSM2

12

20

Small-scale

0.980

High

818039

LSM4
LSM complex subunit LSM4

9

20

Small-scale

0.974

High

945352

LSM6
LSM complex subunit LSM6

9

20

Small-scale

0.973

High

678723

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

10

10

Small-scale

0.972

High

818478

LSM5
LSM complex subunit LSM5

9

18

Small-scale

0.972

High

924553

LSM7
LSM complex subunit LSM7

8

20

Small-scale

0.968

High

892970

SART3
U4/U6 snRNA-associated-splicing factor PRP24

7

9

Small-scale

0.956

High

865275

LSM8
LSM2-LSM8 complex subunit LSM8

6

20

Small-scale

0.945

High

780205

SN114
Pre-mRNA-splicing factor SNU114

6

14

Small-scale

0.938

High

945346

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

5

12

Small-scale

0.915

High

817142

RSMB
Small nuclear ribonucleoprotein-associated protein B

5

19

Small-scale

0.908

High

945340

LSM3
LSM complex subunit LSM3

4

19

Small-scale

0.906

High

751771

PRP8
Pre-mRNA-splicing factor 8

4

9

Small-scale

0.875

High

945362

RUXE
Small nuclear ribonucleoprotein E

2

16

Small-scale

0.768

High

945351

SMD2
Small nuclear ribonucleoprotein Sm D2

2

14

Small-scale

0.754

High

744145

BRR2
Pre-mRNA-splicing helicase BRR2

8

20

Small-scale

0.741

High

645498

XRN1
5'-3' exoribonuclease 1

7

5

Small-scale

0.741

High

847814

SMD3
Small nuclear ribonucleoprotein Sm D3

2

20

High-throughput

0.737

High

812101

DHH1
ATP-dependent RNA helicase DHH1

5

12

Small-scale

0.708

High

627863

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

5

20

Small-scale

0.706

High

625038

PRP6
Pre-mRNA-splicing factor 6

4

20

Small-scale

0.678

High

886347

PRP31
Pre-mRNA-processing factor 31

4

10

Small-scale

0.678

High

945364

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

4

11

Small-scale

0.672

High

921126

DCP2
m7GpppN-mRNA hydrolase

3

1

High-throughput

0.647

High

721650

RENT1
ATP-dependent helicase NAM7

3

8

Small-scale

0.642

High

945356

DIB1
Spliceosomal protein DIB1

3

6

Small-scale

0.633

High

394814

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.618

High

945343

SMD1
Small nuclear ribonucleoprotein Sm D1

1

14

High-throughput

0.618

High

945367

DCP1
mRNA-decapping enzyme subunit 1

2

3

Small-scale

0.601

High

849873

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

Small-scale

0.586

High

625115

PRP9
Pre-mRNA-splicing factor PRP9

1

5

High-throughput

0.575

High

945359

RU2A
U2 small nuclear ribonucleoprotein A'

1

10

High-throughput

0.575

High

531847

RL4A
Large ribosomal subunit protein uL4A

2

1

Small-scale

0.571

High

527422

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

545897

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

776632

DEF1
RNA polymerase II degradation factor 1

1

2

High-throughput

0.541

High

678990

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.518

High

726238

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.518

High

761133

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.518

High

816665

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.515

High

945349

SWR1
Helicase SWR1

1

4

High-throughput

0.515

High

533481

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.508

High

643275

BAS1
Myb-like DNA-binding protein BAS1

1

3

High-throughput

0.508

High

745490

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

1

High-throughput

0.508

High

775952

LRG1
Rho-GTPase-activating protein LRG1

1

3

High-throughput

0.508

High

874373

BRO1
Vacuolar-sorting protein BRO1

1

1

High-throughput

0.508

High

689601

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.486

High

798455

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.486

High

820943

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.486

High

453982

IF4E
Eukaryotic translation initiation factor 4E

1

2

Small-scale

0.479

High

579890

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

677520

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

743778

RML2
Large ribosomal subunit protein uL2m

1

3

High-throughput

0.479

High

783943

RM07
Large ribosomal subunit protein uL5m

1

3

High-throughput

0.479

High

885054

RL4B
Large ribosomal subunit protein uL4B

1

1

Small-scale

0.479

High

945347

RM01
Large ribosomal subunit protein uL1m

1

5

High-throughput

0.479

High

945353

MHR1
Large ribosomal subunit protein mL67

1

3

High-throughput

0.479

High

945358

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.479

High

945360

CLF1
Pre-mRNA-splicing factor CLF1

1

20

Small-scale

0.479

High

945361

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.479

High

738684

EI2BB
Translation initiation factor eIF2B subunit beta

1

3

High-throughput

0.464

High

797158

AIM3
Altered inheritance of mitochondria protein 3

1

3

High-throughput

0.464

High

866238

IML1
Vacuolar membrane-associated protein IML1

1

2

High-throughput

0.464

High

919074

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.458

High

945366

NOT5
General negative regulator of transcription subunit 5

1

1

High-throughput

0.457

High

403618

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

High-throughput

0.445

High

427401

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

510722

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

524836

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

597243

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.445

High

671682

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

676253

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

739182

PRP19
Pre-mRNA-processing factor 19

1

17

Small-scale

0.445

High

739262

PRP21
Pre-mRNA-splicing factor PRP21

1

7

High-throughput

0.445

High

752603

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

792185

GBLP
Small ribosomal subunit protein RACK1

1

9

High-throughput

0.445

High

813364

PRP39
Pre-mRNA-processing factor 39

1

20

High-throughput

0.445

High

892771

SF3B1
U2 snRNP component HSH155

1

9

High-throughput

0.445

High

945341

PRP38
Pre-mRNA-splicing factor 38

1

1

High-throughput

0.445

High

945344

CUS1
Cold sensitive U2 snRNA suppressor 1

1

6

High-throughput

0.445

High

945348

RSE1
Pre-mRNA-splicing factor RSE1

1

6

High-throughput

0.445

High

945357

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.445

High

945363

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.445

High

554632

RM02
Large ribosomal subunit protein bL27m

1

3

High-throughput

0.437

High

569511

RM31
Large ribosomal subunit protein mL60

1

3

High-throughput

0.437

High

628172

RM33
Large ribosomal subunit protein uL30m

1

3

High-throughput

0.437

High

647935

RM08
Large ribosomal subunit protein bL17m

1

3

High-throughput

0.437

High

648003

RM20
Large ribosomal subunit protein mL58

1

3

High-throughput

0.437

High

657463

RM25
Large ribosomal subunit protein mL59

1

3

High-throughput

0.437

High

672557

RM32
Large ribosomal subunit protein bL32m

1

2

High-throughput

0.437

High

678203

IMG1
Large ribosomal subunit protein bL19m

1

3

High-throughput

0.437

High

678612

IMG2
Large ribosomal subunit protein mL49

1

3

High-throughput

0.437

High

725744

RM09
Large ribosomal subunit protein uL3m

1

4

High-throughput

0.437

High

736294

RM41
Large ribosomal subunit protein uL23m

1

3

High-throughput

0.437

High

758014

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

1

High-throughput

0.437

High

778231

RM38
Large ribosomal subunit protein uL14m

1

3

High-throughput

0.437

High

783811

RM03
Large ribosomal subunit protein mL44

1

3

High-throughput

0.437

High

784010

RM10
Large ribosomal subunit protein uL15m

1

3

High-throughput

0.437

High

784182

RM24
Large ribosomal subunit protein bL28m

1

3

High-throughput

0.437

High

784226

RM27
Large ribosomal subunit protein mL41

1

3

High-throughput

0.437

High

784277

RM28
Large ribosomal subunit protein mL40

1

3

High-throughput

0.437

High

784342

RM17
Large ribosomal subunit protein mL46

1

3

High-throughput

0.437

High

784398

RM36
Large ribosomal subunit protein bL31m

1

2

High-throughput

0.437

High

784462

RM39
Large ribosomal subunit protein bL33m

1

3

High-throughput

0.437

High

784502

RM40
Large ribosomal subunit protein uL24m

1

3

High-throughput

0.437

High

792636

RM16
Large ribosomal subunit protein uL16m

1

3

High-throughput

0.437

High

828556

RN49
Large ribosomal subunit protein bL21m

1

3

High-throughput

0.437

High

909787

RL4P
Large ribosomal subunit protein uL4m

1

3

High-throughput

0.437

High

918423

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.437

High

922928

RM50
Large ribosomal subunit protein bL9m

1

3

High-throughput

0.437

High

924280

RM22
Large ribosomal subunit protein uL22m

1

3

High-throughput

0.437

High

945342

RM13
Large ribosomal subunit protein mL50

1

3

High-throughput

0.437

High

945355

RM35
Large ribosomal subunit protein mL38

1

3

High-throughput

0.437

High

945365

RM23
Large ribosomal subunit protein uL13m

1

3

High-throughput

0.437

High

435283

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.426

High

945354

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

739110

PT309
Mitochondrial COX1 translation regulator PET309

1

0

High-throughput

0.265

Low

945350

YL281
Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial

1

0

High-throughput

0.265

Low

268897

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

554529

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

945345

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025