HitPredict

Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Interactor 2: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 750 Hs			1 2364
+	Mm
		786538 STAT3_MOUSE (1-740): 0: 865: 52.61		SPTB2_MOUSE (1-2364): 0: 742: 98.31
+	Hs
		211521 STAT1_HUMAN (1-750): 0: 988: 100.00		ACTN4_HUMAN (53-525): 6.51e-121: 409: 47.58
+	Hs
		506810 STAT1_HUMAN (1-750): 0: 988: 100.00		SPTB1_HUMAN (1359-2356): 5.1e-25: 117: 13.42
+	Hs
		786343 STAT1_HUMAN (1-750): 0: 988: 100.00		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		786352 STAT1_HUMAN (1-750): 0: 988: 100.00		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59
+	Hs
		786483 STAT6_HUMAN (1-740): 0: 638: 26.43		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59