Protein: 2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta)

Gene: 2ABD, PPP2R2D
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q66LE6

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0000278 - mitotic cell cycle
GO:0005829 - cytosol
GO:0010458 - exit from mitosis
GO:0019888 - protein phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717854

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

9

10

Small-scale

0.757

High

994262

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

8

20

Small-scale

0.754

High

977520

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

7

20

High-throughput

0.750

High

58730

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

6

7

High-throughput

0.732

High

718133

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

5

10

High-throughput

0.722

High

1226737

DMAP1
DNA methyltransferase 1-associated protein 1

5

1

High-throughput

0.722

High

991046

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

5

7

High-throughput

0.720

High

1226725

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

5

2

High-throughput

0.716

High

951991

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

4

19

High-throughput

0.706

High

1226702

SKA3
Spindle and kinetochore-associated protein 3

4

2

High-throughput

0.704

High

1226729

CDCA4
Cell division cycle-associated protein 4

4

9

High-throughput

0.699

High

1091116

FOXC1
Forkhead box protein C1

3

15

High-throughput

0.675

High

1226759

CIA30
Complex I intermediate-associated protein 30, mitochondrial

3

2

High-throughput

0.675

High

1226761

PPME1
Protein phosphatase methylesterase 1

6

2

High-throughput

0.672

High

340345

YETS4
YEATS domain-containing protein 4

4

0

High-throughput

0.667

High

1023803

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

3

7

High-throughput

0.662

High

1226687

ZCHC8
Zinc finger CCHC domain-containing protein 8

5

3

High-throughput

0.659

High

1226762

RBM7
RNA-binding protein 7

5

8

High-throughput

0.657

High

1226740

SRTD4
SERTA domain-containing protein 4

5

3

High-throughput

0.654

High

1102333

GRB10
Growth factor receptor-bound protein 10

3

5

High-throughput

0.650

High

1226727

IER2
Immediate early response gene 2 protein

4

8

High-throughput

0.638

High

1219253

IER5
Immediate early response gene 5 protein

4

8

High-throughput

0.636

High

821405

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.635

High

876011

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.635

High

881974

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.635

High

899433

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.635

High

1007074

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.635

High

1226722

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.635

High

1226718

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

4

7

High-throughput

0.630

High

610711

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.628

High

841193

CNDD3
Condensin-2 complex subunit D3

2

4

High-throughput

0.628

High

862869

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

2

High-throughput

0.628

High

1200938

SGO2
Shugoshin 2

2

1

High-throughput

0.628

High

1226711

COP1
E3 ubiquitin-protein ligase COP1

2

3

High-throughput

0.628

High

1226751

ZBT21
Zinc finger and BTB domain-containing protein 21

2

2

High-throughput

0.628

High

1226753

ZN232
Zinc finger protein 232

2

1

High-throughput

0.628

High

838737

MTREX
Exosome RNA helicase MTR4

3

5

High-throughput

0.619

High

226978

ENSA
Alpha-endosulfine

2

3

High-throughput

0.612

High

347101

BAG2
BAG family molecular chaperone regulator 2

2

2

High-throughput

0.611

High

1025558

CDK16
Cyclin-dependent kinase 16

2

6

High-throughput

0.611

High

143742

WN10B
Protein Wnt-10b

3

2

High-throughput

0.609

High

221940

FOXS1
Forkhead box protein S1

3

15

High-throughput

0.609

High

430025

JUN
Transcription factor Jun

3

5

High-throughput

0.609

High

942159

WNT3A
Protein Wnt-3a

3

2

High-throughput

0.609

High

1187837

FX4L6
Forkhead box protein D4-like 6

3

15

High-throughput

0.609

High

1226709

CBLL2
E3 ubiquitin-protein ligase CBLL2

3

4

High-throughput

0.609

High

1091188

FOXD4
Forkhead box protein D4

3

13

High-throughput

0.604

High

1226728

RFIP5
Rab11 family-interacting protein 5

3

3

High-throughput

0.604

High

1226757

GSTK1
Glutathione S-transferase kappa 1

2

0

High-throughput

0.602

High

1121160

SRTD2
SERTA domain-containing protein 2

2

7

High-throughput

0.601

High

241977

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

144100

WNT7A
Protein Wnt-7a

2

2

High-throughput

0.574

High

244715

ZC3H1
Zinc finger C3H1 domain-containing protein

2

1

High-throughput

0.574

High

377312

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

2

1

High-throughput

0.574

High

583569

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

5

High-throughput

0.574

High

605261

ATF7
Cyclic AMP-dependent transcription factor ATF-7

2

5

High-throughput

0.574

High

1039761

CREB5
Cyclic AMP-responsive element-binding protein 5

2

6

High-throughput

0.574

High

1226697

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

1226719

ZN414
Zinc finger protein 414

2

1

High-throughput

0.574

High

1226754

TRI35
E3 ubiquitin-protein ligase TRIM35

2

1

High-throughput

0.574

High

711369

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.571

High

353818

PTTG1
Securin

1

0

Small-scale

0.561

High

1214706

ATD3B
ATPase family AAA domain-containing protein 3B

2

8

High-throughput

0.558

High

920826

ACLY
ATP-citrate synthase

1

3

High-throughput

0.554

High

563903

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

849188

KSYK
Tyrosine-protein kinase SYK

1

5

High-throughput

0.536

High

899084

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

932577

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

3

High-throughput

0.536

High

973470

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

1129062

RASA3
Ras GTPase-activating protein 3

1

1

High-throughput

0.536

High

1226700

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.536

High

1226715

ATX2L
Ataxin-2-like protein

1

2

High-throughput

0.536

High

1226758

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

7

High-throughput

0.536

High

1226732

SKI8
Superkiller complex protein 8

1

0

High-throughput

0.530

High

920459

DAPK1
Death-associated protein kinase 1

1

1

Small-scale

0.528

High

384443

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

568656

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

1161788

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1226705

TRM2A
tRNA

1

0

High-throughput

0.513

High

1226726

FSP1
Ferroptosis suppressor protein 1

1

0

High-throughput

0.513

High

1226742

BEX4
Protein BEX4

1

0

High-throughput

0.513

High

1226748

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.513

High

1226689

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.506

High

1226708

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

High-throughput

0.506

High

508129

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

69789

ZN785
Zinc finger protein 785

1

1

High-throughput

0.489

High

163503

ZN213
Zinc finger protein 213

1

2

High-throughput

0.489

High

503605

TFPT
TCF3 fusion partner

1

1

High-throughput

0.489

High

665983

IBP5
Insulin-like growth factor-binding protein 5

1

3

High-throughput

0.489

High

1091068

FOXF2
Forkhead box protein F2

1

15

High-throughput

0.489

High

1226691

CAN12
Calpain-12

1

3

High-throughput

0.489

High

1226692

BT2A1
Butyrophilin subfamily 2 member A1

1

1

High-throughput

0.489

High

1226695

PBIR2
PABIR family member 2

1

7

High-throughput

0.489

High

1226724

FOXC2
Forkhead box protein C2

1

15

High-throughput

0.489

High

1226739

FX4L1
Forkhead box protein D4-like 1

1

15

High-throughput

0.489

High

1226741

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

High-throughput

0.489

High

1226743

NHSL3
NHS-like protein 3

1

4

High-throughput

0.489

High

1226749

SRTD1
SERTA domain-containing protein 1

1

1

High-throughput

0.489

High

1226750

FOXD3
Forkhead box protein D3

1

14

High-throughput

0.489

High

1226760

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.489

High

221800

SNAI2
Zinc finger protein SNAI2

1

1

Small-scale

0.479

High

719338

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

767062

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

2

High-throughput

0.479

High

888126

MCM2
DNA replication licensing factor MCM2

1

11

High-throughput

0.479

High

990341

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.479

High

1060789

ACK1
Activated CDC42 kinase 1

1

3

High-throughput

0.479

High

1143888

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

Small-scale

0.479

High

1178195

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1193533

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

1226712

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.479

High

1226716

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.479

High

1226723

DUS9
Dual specificity protein phosphatase 9

1

4

High-throughput

0.479

High

1226730

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.479

High

1226746

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

1226747

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1226755

HDAC5
Histone deacetylase 5

1

7

High-throughput

0.479

High

1226763

DUS10
Dual specificity protein phosphatase 10

1

4

High-throughput

0.479

High

1116756

AAMP
Angio-associated migratory cell protein

1

0

High-throughput

0.458

High

1218583

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

336443

SVIL
Supervillin

1

4

High-throughput

0.445

High

934734

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

940368

ARP19
cAMP-regulated phosphoprotein 19

1

3

High-throughput

0.445

High

1226704

ULK2
Serine/threonine-protein kinase ULK2

1

10

High-throughput

0.445

High

1226731

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.445

High

1226736

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1226738

ECHD1
Ethylmalonyl-CoA decarboxylase

1

4

High-throughput

0.445

High

208517

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

279394

TULP3
Tubby-related protein 3

1

1

High-throughput

0.437

High

315686

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.437

High

827425

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.437

High

1143834

TCAL1
Transcription elongation factor A protein-like 1

1

2

High-throughput

0.437

High

1226688

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

1226734

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1130299

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1226721

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

130503

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.417

High

174842

MAST4
Microtubule-associated serine/threonine-protein kinase 4

1

12

High-throughput

0.407

High

175504

KHNYN
Protein KHNYN

1

1

High-throughput

0.407

High

704975

RBL1
Retinoblastoma-like protein 1

1

1

High-throughput

0.407

High

1063051

S20A2
Sodium-dependent phosphate transporter 2

1

2

High-throughput

0.407

High

1226693

ATOSB
Atos homolog protein B

1

2

High-throughput

0.407

High

1226701

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

1226703

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.407

High

1226720

Q96T67
TOB3

1

8

High-throughput

0.407

High

1226733

SIK2
Serine/threonine-protein kinase SIK2

1

7

High-throughput

0.407

High

63139

CL18A
C-type lectin domain family 18 member A

3

0

High-throughput

0.347

High

569253

YJU2B
Probable splicing factor YJU2B

3

0

High-throughput

0.347

High

1226713

PKHO2
Pleckstrin homology domain-containing family O member 2

3

0

High-throughput

0.347

High

1013145

SARNP
SAP domain-containing ribonucleoprotein

2

0

High-throughput

0.328

High

1226696

ZN550
Zinc finger protein 550

2

0

High-throughput

0.328

High

1226698

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.328

High

1226699

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.328

High

1226707

CA087
Uncharacterized protein C1orf87

2

0

High-throughput

0.328

High

1226710

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

908632

PRELP
Prolargin

2

0

High-throughput

0.318

High

171889

ZN263
Zinc finger protein 263

1

0

High-throughput

0.279

Low

351758

SG1D2
Secretoglobin family 1D member 2

1

0

High-throughput

0.279

Low

477336

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

528463

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.279

Low

559690

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.279

Low

725072

HXC8
Homeobox protein Hox-C8

1

0

High-throughput

0.279

Low

1005527

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

0

High-throughput

0.279

Low

1009222

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1052875

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.279

Low

1226690

DPPA3
Developmental pluripotency-associated protein 3

1

0

High-throughput

0.279

Low

1226694

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.279

Low

1226706

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

1226714

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1226735

PIF1
ATP-dependent DNA helicase PIF1

1

0

High-throughput

0.279

Low

1226744

SPMA2
Sperm microtubule associated protein 2

1

0

High-throughput

0.279

Low

1226752

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

351856

BMP15
Bone morphogenetic protein 15

1

0

High-throughput

0.249

Low

353389

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

574018

HXB2
Homeobox protein Hox-B2

1

0

High-throughput

0.249

Low

1226717

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

1178804

KIZ
Centrosomal protein kizuna

1

0

High-throughput

0.232

Low

1226745

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low

1226756

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025