HitPredict

Interactor 1: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	15652752, 9742102
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 794 Hs			1 258
+	Mm
		786656 STA5A_MOUSE (1-794): 0: 1043: 96.35		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		849911 STA5B_HUMAN (1-774): 0: 997: 93.84		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		146672 STA5A_HUMAN (1-794): 0: 1050: 100.00		SOCS7_HUMAN (43-256): 3.74e-43: 155: 25.93
+	Hs
		146609 STA5B_HUMAN (1-774): 0: 997: 93.84		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		786601 STA5A_HUMAN (1-794): 0: 1050: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Mm
		719288 STA5A_MOUSE (1-794): 0: 1043: 96.35		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		849884 STA5B_HUMAN (1-774): 0: 997: 93.84		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		849903 STA5B_HUMAN (1-774): 0: 997: 93.84		P55G_HUMAN (53-183): 1.06e-21: 95.3: 15.27
+	Hs
		522836 STAT1_HUMAN (1-724): 0: 755: 28.09		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		256851 STAT1_HUMAN (1-724): 0: 755: 28.09		SOCS5_HUMAN (59-257): 3.09e-41: 149: 25.87
+	Hs
		147400 STAT3_HUMAN (1-723): 0: 736: 29.94		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		146671 STAT3_HUMAN (1-723): 0: 736: 29.94		SOCS7_HUMAN (43-256): 3.74e-43: 155: 25.93
+	Mm
		403422 STAT3_MOUSE (1-723): 0: 737: 29.94		SRC_MOUSE (50-248): 7.06e-42: 151: 16.11
+	Hs
		412065 STAT3_HUMAN (1-723): 0: 736: 29.94		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		442788 STAT3_HUMAN (1-723): 0: 736: 29.94		HCK_HUMAN (47-215): 1.32e-41: 150: 15.82
+	Hs
		411624 STAT3_HUMAN (1-723): 0: 736: 29.94		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Mm
		193377 STAT3_MOUSE (1-723): 0: 737: 29.94		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Hs
		786325 STAT1_HUMAN (1-724): 0: 755: 28.09		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		129229 STAT3_HUMAN (1-723): 0: 736: 29.94		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		433628 STAT3_HUMAN (1-723): 0: 736: 29.94		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21