HitPredict

Interactor 1: MTREX (P42285)
Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)
Gene: MTREX

Interactor 2: EXOS1 (Q9Y3B2)
Exosome complex component CSL4 (Exosome component 1)
Gene: EXOSC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006364 - rRNA processing and 1 others more... GO:0006401 - RNA catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1042 Hs			1 195
+	Hs
		786945 MTREX_HUMAN (1-1042): 0: 899: 100.00		EXOS2_HUMAN (7-174): 3.42e-57: 183: 19.19
+	Sp
		145116 MTR4_SCHPO (4-1042): 0: 742: 54.07		RRP4_SCHPO (7-152): 1.21e-55: 180: 21.92
+	Sc
		754969 MTR4_YEAST (61-1042): 0: 723: 52.39		RRP4_YEAST (6-152): 8.24e-53: 174: 21.77
+	Sc
		810890 MTR4_YEAST (61-1042): 0: 723: 52.39		CSL4_YEAST (64-187): 7.62e-38: 133: 36.25
+	Sp
		143129 YE02_SCHPO (22-1042): 0: 669: 46.04		RRP4_SCHPO (7-152): 1.21e-55: 180: 21.92
+	Sc
		716179 SKI2_YEAST (6-1042): 0: 580: 31.41		RRP4_YEAST (6-152): 8.24e-53: 174: 21.77
+	Sc
		716198 SKI2_YEAST (6-1042): 0: 580: 31.41		CSL4_YEAST (64-187): 7.62e-38: 133: 36.25
+	Sp
		624018 DBP2_SCHPO (45-572): 6.31e-90: 300: 12.70		RRP4_SCHPO (7-152): 1.21e-55: 180: 21.92