Protein: C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)

Gene: C1TM, MTHFD1L
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q6UB35

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348574

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

2

High-throughput

0.643

High

1113455

CUL3
Cullin-3

2

3

High-throughput

0.611

High

841795

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

High-throughput

0.585

High

372352

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.585

High

1162385

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1247880

SYMM
Methionine--tRNA ligase, mitochondrial

2

0

High-throughput

0.576

High

396357

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1247886

TR61B
tRNA

2

1

High-throughput

0.571

High

1247919

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

2

0

High-throughput

0.559

High

127692

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.536

High

772864

MYH9
Myosin-9

1

1

High-throughput

0.536

High

854123

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

923390

MK10
Mitogen-activated protein kinase 10

1

2

High-throughput

0.536

High

969927

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1247872

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1247920

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1135716

HAPR1
HUWE1-associated protein modifying stress responses 1

2

1

Small-scale

0.533

High

275316

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

278681

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

447133

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

867219

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

1122513

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.513

High

1238399

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1242585

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1247862

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

High-throughput

0.513

High

1247863

TPC6B
Trafficking protein particle complex subunit 6B

1

0

High-throughput

0.513

High

1247871

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.513

High

1247875

MARC2
Mitochondrial amidoxime reducing component 2

1

0

High-throughput

0.513

High

1247879

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1247890

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1247891

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1247915

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1247917

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.513

High

169605

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.501

High

885699

CASP4
Caspase-4

1

0

High-throughput

0.493

High

1247924

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.493

High

887434

CEBPD
CCAAT/enhancer-binding protein delta

1

5

High-throughput

0.489

High

132111

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

242041

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

279802

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

293882

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315703

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

319851

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324159

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.479

High

340902

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.479

High

350051

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

412121

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

458434

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

471094

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519144

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532689

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

537368

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

610010

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.479

High

650240

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.479

High

777709

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.479

High

787038

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.479

High

828817

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

830946

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

845319

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

High-throughput

0.479

High

851929

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856295

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

883266

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

897870

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

970673

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

984165

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

1015536

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

1058093

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1087429

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

1090441

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1092158

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

1104425

ILK
Scaffold protein ILK

1

1

High-throughput

0.479

High

1106967

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1128752

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1138329

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1140446

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1142576

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1178213

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1207049

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1234422

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1247865

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

1247867

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1247868

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1247870

ASB12
Ankyrin repeat and SOCS box protein 12

1

5

High-throughput

0.479

High

1247873

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1247874

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1247876

OPTN
Optineurin

1

2

High-throughput

0.479

High

1247882

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1247884

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1247888

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1247893

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

1247895

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.479

High

1247897

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1247898

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1247899

NEK6
Serine/threonine-protein kinase Nek6

1

2

High-throughput

0.479

High

1247901

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1247902

ANLN
Anillin

1

2

High-throughput

0.479

High

1247904

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1247905

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1247911

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1247914

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1247916

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

1247913

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.470

High

125506

LEG9
Galectin-9

1

0

High-throughput

0.458

High

252463

DIAP1
Protein diaphanous homolog 1

1

0

High-throughput

0.458

High

559993

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

567428

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

693006

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

788945

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

982709

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1136542

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

1147620

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.458

High

1152434

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

1229534

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1247878

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1247881

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1247883

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1247885

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1247887

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1247892

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1247907

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1247909

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1247910

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

437709

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

869183

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.445

High

943975

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

1135896

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

1247894

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

1247925

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

521764

H14
Histone H1.4

1

1

High-throughput

0.437

High

588965

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695750

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768473

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

879205

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1100027

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

1155474

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1180227

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.437

High

1186108

ANR55
Ankyrin repeat domain-containing protein 55

1

5

High-throughput

0.437

High

1247861

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1247864

HOOK3
Protein Hook homolog 3

1

3

High-throughput

0.437

High

1247866

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1247869

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1247889

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1247896

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1247903

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

1247906

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1247912

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

1247918

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.437

High

1247921

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

777615

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.426

High

430052

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

1197798

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.407

High

1247877

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1247900

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1247908

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

1247922

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1247923

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025