HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: LST8 (Q9BVC4)
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)
Gene: MLST8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 12408816, 26186194, 28514442, 28489822, 27909983, 20562859, 12718876, 22084251, 17277771, 27173435, 18504440, 16183647, 15066126, 12719976, 32433973, 34171383, 35973513, 20427287, 16798736, 15459249 and 12 others

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Identification Methods affinity chromatography technology, biochemical, pull down, molecular sieving, x-ray crystallography, ion exchange chromatography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PI3_PI4_kinase~WD40
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0006974 - DNA damage response
and 17 others

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Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 2549
Hs

1 326
+ Mm
+ Hs
+ Dm
+ Sp
+ Sc
+ At
+ At
+ Sp
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Sc

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Last updated: 15 Jul 2024