HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	31723608, 17626244
Identification Methods	proximity labelling technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 577
+	Hs
		787920 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Cl
		47357 A0A8I3PJA6_CANLF (1-896): 5.87e-149: 464: 92.91		F1PHV6_CANLF (160-556): 6.38e-28: 121: 15.31
+	Hs
		724698 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Mm
		788010 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Hs
		1078919 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Rn
		222476 MRCKB_RAT (227-886): 5.86e-43: 172: 11.89		MRCKA_RAT (87-531): 8.04e-29: 124: 15.29
+	Hs
		1078828 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		259644 LIPA2_HUMAN (210-884): 2.13e-31: 134: 11.53		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		1268126 MRCKB_HUMAN (223-886): 2.4e-41: 167: 12.72		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Rn
		1186812 MRCKB_RAT (227-886): 5.86e-43: 172: 11.89		MRCKB_RAT (39-551): 1.19e-09: 63.5: 12.19
+	Hs
		1078923 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Rn
		92844 E9PSY8_RAT (9-333): 4.64e-17: 88.3: 11.66		ITSN1_RAT (38-416): 1.68e-18: 92: 13.13
+	Hs
		522585 MYH7_HUMAN (256-608): 1.36e-14: 80.6: 11.14		MYH7_HUMAN (171-563): 8.39e-15: 80.3: 16.29
+	Rn
		361106 MYH6_RAT (263-672): 2.44e-15: 83.3: 12.47		MYH6_RAT (226-544): 4.65e-12: 71.4: 14.73
+	Hs
		522657 MYH7_HUMAN (256-608): 1.36e-14: 80.6: 11.14		MYH4_HUMAN (226-567): 2.08e-10: 66: 12.10
+	Mm
		1141846 EP15R_MOUSE (417-895): 9.06e-11: 67.9: 12.27		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09