HitPredict

Interactor 1: EPS15 (P42567)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: AP2B1 (Q9DBG3)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9182572
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030122 - AP-2 adaptor complex GO:0045202 - synapse GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 897 Mm			1 937
+	Hs
		787890 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		787903 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Rn
		923853 Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33		AP2B1_RAT (1-937): 0: 924: 99.89
+	Hs
		321504 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Hs
		302112 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		AP2A2_HUMAN (11-933): 0: 604: 16.89
+	Hs
		925876 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		925895 FKB15_HUMAN (80-884): 4.86e-39: 159: 10.67		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Mm
		567515 EPS15_MOUSE (1-897): 1.37e-149: 465: 100.00		AP2A2_MOUSE (11-932): 0: 600: 16.29
+	Rn
		923861 ITSN1_RAT (124-817): 1.9e-33: 141: 15.09		AP2B1_RAT (1-937): 0: 924: 99.89
+	Hs
		1014017 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Hs
		926031 ITSN2_HUMAN (6-552): 2.33e-26: 118: 11.31		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		212604 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		AP1G1_HUMAN (11-808): 0: 549: 17.57
+	Rn
		88764 Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33		D3ZUY8_RAT (11-932): 0: 625: 17.04
+	Hs
		1014096 ITSN2_HUMAN (6-552): 2.33e-26: 118: 11.31		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Rn
		1126749 Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33		Q66HM2_RAT (11-932): 0: 595: 16.17
+	Hs
		321552 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Rn
		88768 ITSN1_RAT (124-817): 1.9e-33: 141: 15.09		D3ZUY8_RAT (11-932): 0: 625: 17.04
+	Hs
		302157 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		AP2A2_HUMAN (11-933): 0: 604: 16.89
+	Hs
		321615 REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Hs
		302193 REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21		AP2A2_HUMAN (11-933): 0: 604: 16.89