HitPredict

Interactor 1: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Interactor 2: PIDD1 (Q9HB75)
p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]
Gene: PIDD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

The method score is based on:

Property	Details
Experiments	15073321, 22854598, 16360037, 21415862, 16652156
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CARD~Death
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process and 5 others more... GO:0006974 - DNA damage response GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:1905369 - endopeptidase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	452
Hs

1	910

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024