HitPredict

Interactor 1: TEC (P42680)
Tyrosine-protein kinase Tec (EC 2.7.10.2)
Gene: TEC

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol GO:0042246 - tissue regeneration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 780
+	Hs
		441187 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		616906 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		788993 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		441169 SRC_HUMAN (127-627): 2.29e-166: 487: 35.24		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		617085 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		616962 BMX_HUMAN (1-627): 0: 605: 45.05		PTPRD_HUMAN (8-299): 1.81e-94: 325: 32.32
+	Hs
		337361 ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		788996 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		788988 TEC_HUMAN (1-631): 0: 738: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		337339 ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Mm
		337619 ABL1_MOUSE (143-624): 9.94e-170: 515: 37.50		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		522804 SRC_HUMAN (127-627): 2.29e-166: 487: 35.24		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		789088 ABL2_HUMAN (124-631): 7.96e-168: 512: 36.59		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Hs
		522755 SRC_HUMAN (127-627): 2.29e-166: 487: 35.24		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		522754 SRC_HUMAN (127-627): 2.29e-166: 487: 35.24		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Dm
		337644 ABL_DROME (174-624): 4.06e-165: 514: 38.07		LAR_DROME (8-302): 1.8e-92: 319: 30.33
+	Hs
		522756 SRC_HUMAN (127-627): 2.29e-166: 487: 35.24		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Dm
		337643 ABL_DROME (174-624): 4.06e-165: 514: 38.07		PTP69_DROME (7-298): 8.96e-74: 264: 26.25
+	Dm
		337647 ABL_DROME (174-624): 4.06e-165: 514: 38.07		PTP99_DROME (10-319): 2.98e-44: 174: 21.07
+	Dm
		442751 BTKL_DROME (143-619): 2.64e-170: 506: 50.81		PTP10_DROME (58-295): 6.75e-42: 167: 36.98