Protein: ACV1B
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)

Gene: ACV1B, ACVR1B
Organism: Homo sapiens
Interactions: 101
UniProt ID: P36896

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001701 - in utero embryonic development
GO:0001942 - hair follicle development
GO:0004674 - protein serine/threonine kinase activity
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690073

AVR2A
Activin receptor type-2A

5

20

Small-scale

0.912

High

787295

AVR2B
Activin receptor type-2B

5

19

Small-scale

0.908

High

470365

INHBA
Inhibin beta A chain

4

20

Small-scale

0.878

High

787289

ACVR1
Activin receptor type-1

3

19

Small-scale

0.847

High

787284

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

7

Small-scale

0.805

High

787278

TGFR2
TGF-beta receptor type-2

2

19

High-throughput

0.789

High

651622

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

2

High-throughput

0.698

High

572906

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

787285

KC1G2
Casein kinase I isoform gamma-2

1

6

High-throughput

0.691

High

787294

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.691

High

787303

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

1

High-throughput

0.691

High

787308

BTNL9
Butyrophilin-like protein 9

1

1

High-throughput

0.691

High

787314

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.691

High

787319

ACV1C
Activin receptor type-1C

1

19

High-throughput

0.691

High

787320

PKR1
Prokineticin receptor 1

1

4

High-throughput

0.691

High

787349

STK36
Serine/threonine-protein kinase 36

1

6

High-throughput

0.691

High

787352

GPR83
G-protein coupled receptor 83

1

2

High-throughput

0.691

High

468136

HS90B
Heat shock protein HSP 90-beta

1

16

High-throughput

0.665

High

787315

AGRG5
Adhesion G-protein coupled receptor G5

3

3

High-throughput

0.662

High

177658

SMAD7
Mothers against decapentaplegic homolog 7

3

20

Small-scale

0.657

High

787321

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.656

High

787336

NODAL
Nodal homolog

1

20

Small-scale

0.647

High

787302

CC50B
Cell cycle control protein 50B

2

3

High-throughput

0.628

High

787330

MRAP2
Melanocortin-2 receptor accessory protein 2

2

5

High-throughput

0.628

High

787281

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.621

High

787296

BMPR2
Bone morphogenetic protein receptor type-2

1

19

Small-scale

0.621

High

700774

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.618

High

411487

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

461220

HS90A
Heat shock protein HSP 90-alpha

1

16

High-throughput

0.618

High

466131

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

483485

INHBB
Inhibin beta B chain

1

20

Small-scale

0.618

High

787283

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

787310

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

787327

HAVR1
Hepatitis A virus cellular receptor 1

1

3

Small-scale

0.618

High

787341

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

212378

SPIT2
Kunitz-type protease inhibitor 2

2

3

High-throughput

0.611

High

561348

TDGF1
Protein Cripto

2

7

Small-scale

0.602

High

787346

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

19

Small-scale

0.601

High

787300

SMAD2
Mothers against decapentaplegic homolog 2

2

20

Small-scale

0.595

High

787342

ZN644
Zinc finger protein 644

1

0

High-throughput

0.578

High

254853

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.575

High

484069

PGFRB
Platelet-derived growth factor receptor beta

1

13

High-throughput

0.575

High

787288

XIAP
E3 ubiquitin-protein ligase XIAP

1

8

Small-scale

0.553

High

564903

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.536

High

787280

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

787301

SGCA
Alpha-sarcoglycan

1

2

High-throughput

0.536

High

787309

I20RB
Interleukin-20 receptor subunit beta

1

8

High-throughput

0.536

High

787317

RELL2
RELT-like protein 2

1

2

High-throughput

0.536

High

787326

BSND
Barttin

1

1

High-throughput

0.536

High

787333

OPALI
Opalin

1

3

High-throughput

0.536

High

787345

CRLF2
Cytokine receptor-like factor 2

1

5

High-throughput

0.536

High

787351

CLDN1
Claudin domain-containing protein 1

1

1

High-throughput

0.536

High

787353

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

787354

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

6

High-throughput

0.536

High

787307

AR26L
Putative ankyrin repeat domain-containing protein 26-like protein

1

4

High-throughput

0.514

High

787337

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

787338

SYT11
Synaptotagmin-11

1

0

High-throughput

0.513

High

787334

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

19

High-throughput

0.512

High

787290

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.501

High

787329

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.501

High

787286

DLK1
Protein delta homolog 1

1

8

High-throughput

0.489

High

787298

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.489

High

787305

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.489

High

787313

T200A
Transmembrane protein 200A

1

2

High-throughput

0.489

High

787318

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.489

High

787324

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

787331

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

787343

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

787347

TMM9B
Transmembrane protein 9B

1

4

High-throughput

0.489

High

625773

RXRA
Retinoic acid receptor RXR-alpha

1

1

High-throughput

0.481

High

130017

PGRC1
Membrane-associated progesterone receptor component 1

1

6

High-throughput

0.479

High

219844

SMAD6
Mothers against decapentaplegic homolog 6

1

20

Small-scale

0.479

High

252662

TSN3
Tetraspanin-3

1

5

High-throughput

0.479

High

787279

HSPA9
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

787287

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

787292

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.479

High

787299

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.479

High

787311

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.479

High

787316

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

787328

TSN17
Tetraspanin-17

1

4

High-throughput

0.479

High

787350

CC50A
Cell cycle control protein 50A

1

3

High-throughput

0.479

High

279564

LAT3
Large neutral amino acids transporter small subunit 3

1

1

High-throughput

0.445

High

388380

B3AT
Band 3 anion transport protein

1

7

High-throughput

0.445

High

787297

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

787325

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

787335

B3A4
Anion exchange protein 4

1

7

High-throughput

0.445

High

787291

OS9
Protein OS-9

1

1

High-throughput

0.439

High

71381

HECA2
HEPACAM family member 2

1

4

High-throughput

0.437

High

255392

SNX2
Sorting nexin-2

1

8

Small-scale

0.437

High

787293

SNX1
Sorting nexin-1

1

9

Small-scale

0.437

High

787306

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

787312

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.437

High

787348

SAR1A
Small COPII coat GTPase SAR1A

1

3

High-throughput

0.437

High

787282

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

8

High-throughput

0.407

High

787304

NTCP5
Sodium/bile acid cotransporter 5

1

3

High-throughput

0.407

High

787322

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

8

High-throughput

0.407

High

787323

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

787340

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

787344

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

787332

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

787339

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025