HitPredict

Interactor 1: ABL2 (P42684)
Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
Gene: ABL2

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 8194526, 15886098, 25814554, 33961781, 19380743, 17474147, unassigned1126
Identification Methods pull down, enzymatic study, two hybrid, affinity chromatography technology, peptide array, two hybrid array, validated two hybrid, protein kinase assay, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0015629 - actin cytoskeleton
GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1182
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Last updated: 15 Jul 2024