HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 1024
+	Hs
		131778 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		WWP2_HUMAN (547-1024): 0: 550: 19.68
+	Hs
		791641 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		NED4L_HUMAN (588-1023): 4.16e-173: 533: 24.31
+	Hs
		791168 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		NEDD4_HUMAN (576-1023): 5.67e-169: 532: 21.99
+	Hs
		791734 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		SMUF2_HUMAN (581-1024): 9.35e-169: 514: 24.29
+	Hs
		791740 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		SMUF1_HUMAN (577-1024): 7.17e-168: 512: 23.54