HitPredict

Interactor 1: PI2R (P43119)
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
Gene: PTGIR

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.878

The method score is based on:

Property Details
Experiments 16460020, 11895442, 16114876, 16352729
Identification Methods x-ray crystallography, affinity chromatography technology, pull down, fluorescent resonance energy transfer
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~G-alpha
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 386
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024