HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 337
+	Hs
		153891 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		793326 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		DLG2_HUMAN (79-232): 1.39e-14: 76.5: 18.63
+	Hs
		793294 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		793312 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		793292 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		793490 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Mm
		1143386 NRCAM_MOUSE (34-642): 1.33e-60: 221: 13.71		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		1195001 NRCAM_MOUSE (34-642): 1.33e-60: 221: 13.71		DLG1_MOUSE (87-235): 9.49e-14: 74.2: 17.31
+	Mm
		530208 NCAM1_MOUSE (255-646): 5.9e-53: 198: 14.98		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		524114 CNTN1_MOUSE (19-642): 6.68e-43: 168: 13.07		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Dm
		1001631 Q9VQW7_DROME (25-345): 8.83e-21: 99.6: 16.42		Q0KHR3_DROME (28-333): 3.13e-36: 141: 22.47
+	Hs
		234545 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19
+	Hs
		234530 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15
+	Hs
		234522 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		DLG2_HUMAN (79-232): 1.39e-14: 76.5: 18.63
+	Hs
		234499 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		234511 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		234509 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05