HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~V-set
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1732
+	Hs
		793543 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		793516 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		793488 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		149131 PXDN_HUMAN (183-555): 5.6e-61: 222: 20.77		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		270448 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		KS6A5_HUMAN (60-334): 2.48e-72: 261: 27.46
+	Hs
		254456 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		793302 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		148187 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Rn
		530226 NCAM1_RAT (11-644): 2.13e-86: 290: 15.78		ROCK1_RAT (371-1052): 2.43e-17: 90.8: 11.90
+	Hs
		1264826 TITIN_HUMAN (50-634): 4.44e-11: 68.6: 11.22		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15