Interactor 1: MSH2 (P43246)
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
Gene: MSH2
Interactor 2: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 10029069, 35271311, 10748159, 15064730, 10783165, 14657349, 9774676, 8942985, 33961781, 21957315, 34591612, 35235311, 37071682, 37140056, 9428522, 19377479, 10856833 |
| Identification Methods | affinity chromatography technology, pull down, biochemical, cross-linking study, ion exchange chromatography, anti tag coimmunoprecipitation, two hybrid |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | MutS_I~MutS_I, MutS_I~MutS_II, MutS_I~MutS_III, MutS_I~MutS_V, MutS_II~MutS_III, MutS_II~MutS_V, MutS_III~MutS_III, MutS_III~MutS_V, MutS_V~MutS_V |
| Common GO terms | GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 12 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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| + | Mm |   |
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| + | Dr | |
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| + | Hs | |
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| + | Hs | |
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| + | At | |
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| + | At | |
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| + | Ce | |
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| + | Sc | |
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| + | Sc | |
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| + | Ec | |
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| + | Sc | |
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| + | At | |
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
