Protein: ISW2
ISWI chromatin-remodeling complex ATPase ISW2 (EC 3.6.4.-) (Imitation switch protein 2)

Gene: ISW2
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: Q08773

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794233

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

17

Small-scale

0.855

High

963771

H3
Histone H3

3

20

Small-scale

0.817

High

744355

CHD1
Chromo domain-containing protein 1

2

17

High-throughput

0.802

High

381301

H2B1
Histone H2B.1

2

20

High-throughput

0.776

High

381663

H2B2
Histone H2B.2

2

20

High-throughput

0.759

High

917407

ITC1
Imitation switch two complex protein 1

12

17

Small-scale

0.756

High

1046897

DPB4
DNA polymerase epsilon subunit D

9

4

Small-scale

0.749

High

382398

H4
Histone H4

2

16

High-throughput

0.737

High

419899

H2A2
Histone H2A.2

2

20

High-throughput

0.737

High

823470

DLS1
Protein DLS1

9

0

Small-scale

0.715

High

1042817

NHP10
Non-histone protein 10

2

20

High-throughput

0.621

High

594614

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.618

High

734487

BTAF1
TATA-binding protein-associated factor MOT1

1

16

Small-scale

0.618

High

547892

NHP6B
Non-histone chromosomal protein 6B

2

20

High-throughput

0.588

High

877591

RFX1
RFX-like DNA-binding protein RFX1

2

7

High-throughput

0.588

High

647851

RFA1
Replication factor A protein 1

2

11

Small-scale

0.584

High

826904

DSN1
Kinetochore-associated protein DSN1

2

4

High-throughput

0.584

High

643672

SNF2
Transcription regulatory protein SNF2

1

16

Small-scale

0.575

High

1064904

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

17

Small-scale

0.575

High

1064908

H2AZ
Histone H2A.Z

1

20

High-throughput

0.575

High

752839

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

808926

UME6
Transcriptional regulatory protein UME6

1

1

Small-scale

0.561

High

358365

ADH1
Alcohol dehydrogenase 1

2

1

High-throughput

0.537

High

483810

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

1

High-throughput

0.536

High

546591

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.536

High

645777

HSP74
Heat shock protein SSA4

1

20

High-throughput

0.536

High

1053875

IMB1
Importin subunit beta-1

1

3

High-throughput

0.536

High

1054168

PDP3
NuA3 HAT complex component PDP3

1

11

Small-scale

0.536

High

1064906

IES3
Ino eighty subunit 3

1

0

High-throughput

0.513

High

680129

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

627809

PYRC
Dihydroorotase

1

1

High-throughput

0.479

High

641450

RCC1
Guanine nucleotide exchange factor SRM1

1

4

Small-scale

0.479

High

708422

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735209

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

745903

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

12

High-throughput

0.479

High

764022

SPT10
Protein SPT10

1

4

High-throughput

0.479

High

818515

SCC4
MAU2 chromatid cohesion factor homolog

1

4

Small-scale

0.479

High

1044809

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

1046194

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.479

High

1053996

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1064905

SCC1
Sister chromatid cohesion protein 1

1

7

High-throughput

0.479

High

585517

KCY
Uridylate kinase

1

0

High-throughput

0.458

High

1045068

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

393472

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.445

High

448234

HAP2
Transcriptional activator HAP2

1

5

High-throughput

0.445

High

481797

HSP73
Heat shock protein SSA3

1

20

High-throughput

0.445

High

510878

HSP77
Import motor subunit, mitochondrial

1

17

High-throughput

0.445

High

527908

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

547834

NHP6A
Non-histone chromosomal protein 6A

1

20

High-throughput

0.445

High

548806

MCM1
Pheromone receptor transcription factor

1

9

High-throughput

0.445

High

550086

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

570816

ABF1
ARS-binding factor 1

1

1

High-throughput

0.445

High

650028

SIN3
Transcriptional regulatory protein SIN3

1

16

High-throughput

0.445

High

671566

SWI4
Regulatory protein SWI4

1

11

High-throughput

0.445

High

727374

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

736746

ASF1
Histone chaperone ASF1

1

11

High-throughput

0.445

High

737655

HIR1
Protein HIR1

1

20

High-throughput

0.445

High

742581

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

742969

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

752993

IXR1
Intrastrand cross-link recognition protein

1

20

High-throughput

0.445

High

754192

MSN2
Zinc finger protein MSN2

1

13

High-throughput

0.445

High

781814

SET3
SET domain-containing protein 3

1

18

High-throughput

0.445

High

804528

SSZ1
Ribosome-associated complex subunit SSZ1

1

15

High-throughput

0.445

High

816451

HSP7E
Heat shock protein SSC3, mitochondrial

1

17

High-throughput

0.445

High

820014

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

820446

RT106
Histone chaperone RTT106

1

3

High-throughput

0.445

High

823055

ATAD2
ATPase histone chaperone YTA7

1

9

High-throughput

0.445

High

858481

TAF1
Transcription initiation factor TFIID subunit 1

1

4

High-throughput

0.445

High

925111

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.445

High

1035344

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

1044163

GIS1
Transcriptional activator/repressor GIS1

1

11

High-throughput

0.445

High

1048419

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.445

High

1064907

CAF1A
Chromatin assembly factor 1 subunit A

1

15

High-throughput

0.445

High

1056442

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.407

High

361016

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

793066

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

793636

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

836233

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

1046613

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025