HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: EPHB3 (P54753)
Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
Gene: EPHB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9674711
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0043087 - regulation of GTPase activity GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 998
+	Hs
		665560 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		EPHB2_HUMAN (39-997): 0: 1214: 69.97
+	Hs
		665378 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		EPHA3_HUMAN (35-996): 0: 1154: 56.44
+	Mm
		1144837 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		Q8BRB1_MOUSE (17-996): 0: 1148: 54.84
+	Hs
		802810 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		EPHA4_HUMAN (17-993): 0: 1155: 56.95
+	Hs
		580937 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		EPHB2_HUMAN (39-997): 0: 1214: 69.97
+	Hs
		855777 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		EPHA4_HUMAN (17-993): 0: 1155: 56.95
+	Hs
		665448 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		EPHA8_HUMAN (11-995): 0: 1070: 48.87
+	Hs
		665168 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		EPHA2_HUMAN (36-991): 0: 1041: 47.27
+	Hs
		411331 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		INSR_HUMAN (295-957): 3.47e-142: 461: 24.71
+	Hs
		435576 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		IGF1R_HUMAN (276-894): 4.3e-141: 458: 25.79
+	Hs
		411332 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		INSR_HUMAN (295-957): 3.47e-142: 461: 24.71
+	Hs
		411288 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		INSR_HUMAN (295-957): 3.47e-142: 461: 24.71
+	Hs
		548695 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		MERTK_HUMAN (281-939): 6.32e-142: 451: 24.05
+	Hs
		411523 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		INSR_HUMAN (295-957): 3.47e-142: 461: 24.71
+	Hs
		435801 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		IGF1R_HUMAN (276-894): 4.3e-141: 458: 25.79
+	Hs
		580942 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		UFO_HUMAN (281-942): 6.02e-149: 467: 24.41
+	Hs
		411292 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		INSR_HUMAN (295-957): 3.47e-142: 461: 24.71
+	Hs
		411981 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		FYN_HUMAN (627-893): 1.18e-61: 221: 42.54
+	Hs
		412098 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		FYN_HUMAN (627-893): 1.18e-61: 221: 42.54
+	Hs
		412000 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		FYN_HUMAN (627-893): 1.18e-61: 221: 42.54