HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	32203420, 8810325, 31980649, 33961781, 8943292, 19380743, unassigned2173, 17474147, unassigned2213
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, peptide array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006357 - regulation of transcription by RNA polymerase II GO:0007165 - signal transduction and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 1333
+	Hs
		802826 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		103875 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		G5E9C8_HUMAN (1-1333): 0: 972: 98.28
+	Mm
		815092 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		SOS1_MOUSE (1-1333): 0: 957: 96.47
+	Hs
		580987 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		802576 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Mm
		1143290 PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43		SOS1_MOUSE (1-1333): 0: 957: 96.47
+	Hs
		802827 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		275188 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		580988 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		802594 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Mm
		1144842 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		Q91ZZ2_MOUSE (593-1032): 1.46e-88: 314: 24.21
+	Hs
		802840 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		548657 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Mm
		1144839 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		Q8C5V7_MOUSE (544-1004): 5.17e-76: 267: 22.68
+	Hs
		156402 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		RGRF2_HUMAN (360-991): 7.8e-85: 305: 17.89
+	Mm
		815095 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		Q8C5V7_MOUSE (544-1004): 5.17e-76: 267: 22.68
+	Hs
		548628 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		548634 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Dm
		284706 CRK_DROME (5-302): 8.8e-52: 173: 43.14		C3G_DROME (776-1024): 1.5e-24: 114: 29.92
+	Mm
		1143293 PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43		RGPS2_MOUSE (774-1023): 3.11e-23: 108: 27.17