HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DSC1 (Q08554)
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)
Gene: DSC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 894
+	Hs
		802776 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PCDA7_HUMAN (3-822): 0: 759: 16.97
+	Hs
		802794 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PCDA8_HUMAN (3-822): 0: 752: 17.28
+	Hs
		802800 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PCDA1_HUMAN (3-822): 0: 752: 16.50
+	Hs
		521790 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		521791 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		522292 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		208984 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		521707 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		522120 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		802795 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PCDA5_HUMAN (1-230): 1.05e-27: 122: 11.25
+	Hs
		802798 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PCDAB_HUMAN (1-230): 1.25e-27: 122: 11.25
+	Hs
		924987 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PCDB5_HUMAN (1-346): 9.32e-53: 199: 18.01
+	Hs
		802544 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		CAD11_HUMAN (30-236): 1.85e-15: 83.1: 15.25