HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10964504
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030159 - signaling receptor complex adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 509
+	Hs
		548712 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		SHB_HUMAN (1-509): 5.37e-127: 381: 100.00
+	Hs
		666036 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		522848 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		666037 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		802854 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		TENS2_HUMAN (43-506): 4.48e-57: 207: 15.20
+	Hs
		433280 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		802558 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		411981 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		789043 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337388 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Mm
		337631 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03
+	Hs
		69205 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		A9UF07_HUMAN (354-507): 2.39e-34: 140: 24.03
+	Hs
		666186 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		802818 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		548677 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		924777 Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		789044 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337389 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Mm
		337621 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03
+	Hs
		337333 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03