HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ASCL4 (Q6XD76)
Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)
Gene: ASCL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 172
+	Hs
		802678 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TWST2_HUMAN (22-167): 3.67e-30: 109: 21.23
+	Hs
		568186 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TAL1_HUMAN (57-161): 7.57e-22: 91.5: 30.28
+	Hs
		924652 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASCL4_HUMAN (1-156): 7.3e-41: 137: 100.00
+	Mm
		603904 VAV_MOUSE (11-189): 7.04e-46: 167: 27.23		TAL1_MOUSE (56-131): 2.67e-10: 59.5: 36.25
+	Hs
		562660 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		TWST2_HUMAN (22-167): 3.67e-30: 109: 21.23
+	Mm
		604045 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		TAL1_MOUSE (56-131): 2.67e-10: 59.5: 36.25
+	Hs
		209095 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		SCX_HUMAN (77-128): 2.06e-10: 58.7: 50.00