HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: K2C73 (Q86Y46)
Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)
Gene: KRT73

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 540
+	Hs
		802644 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C1B_HUMAN (43-463): 2.23e-167: 488: 61.22
+	Hs
		380578 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C1_HUMAN (97-463): 2.77e-157: 464: 66.76
+	Hs
		409026 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C8_HUMAN (104-467): 2.16e-139: 413: 61.26
+	Hs
		802658 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C78_HUMAN (62-461): 1.18e-134: 402: 59.50
+	Hs
		409124 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		K2C8_HUMAN (104-467): 2.16e-139: 413: 61.26
+	Hs
		380590 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C1_HUMAN (97-463): 2.77e-157: 464: 66.76
+	Hs
		444533 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C7_HUMAN (17-459): 1.09e-141: 418: 57.34
+	Hs
		409046 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C8_HUMAN (104-467): 2.16e-139: 413: 61.26
+	Hs
		802619 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C79_HUMAN (18-517): 1.54e-86: 279: 55.03
+	Hs
		380448 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C6B_HUMAN (2-469): 3.05e-79: 260: 57.03
+	Hs
		531539 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C5_HUMAN (1-448): 2.08e-78: 259: 57.65
+	Hs
		359471 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C6A_HUMAN (2-469): 1.45e-75: 251: 57.03
+	Hs
		802568 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K22O_HUMAN (1-460): 1.03e-66: 229: 57.53
+	Hs
		924470 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KRT85_HUMAN (3-447): 6.42e-94: 297: 49.56
+	Hs
		924469 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KRT83_HUMAN (3-495): 2.62e-92: 292: 44.63
+	Hs
		213936 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KRT86_HUMAN (3-504): 1.09e-91: 291: 44.62
+	Hs
		531551 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C5_HUMAN (1-448): 2.08e-78: 259: 57.65
+	Hs
		359480 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C6A_HUMAN (2-469): 1.45e-75: 251: 57.03
+	Mm
		1060206 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q148Q7_MOUSE (1-457): 2.26e-67: 228: 56.41
+	Mm
		1141145 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q8BIS2_MOUSE (1-457): 1.79e-67: 228: 56.41